Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands

被引：23
作者：
Esser, Helen J. [1 ]
Lim, Stephanie M. [2 ]
de Vries, Ankje [3 ]
Sprong, Hein [3 ]
Dekker, Dinant J. [1 ]
Pascoe, Emily L. [1 ]
Bakker, Julian W. [1 ]
Suin, Vanessa [4 ]
Franz, Eelco [3 ]
Martina, Byron E. E. [2 ]
Koenraadt, Constantianus J. M. [1 ]
机构：
[1] Wageningen Univ & Res, Wageningen, Netherlands
[2] Artemis One Hlth Res Inst, Delft, Netherlands
[3] Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands
[4] Sciensano, Brussels, Belgium
来源：
EMERGING INFECTIOUS DISEASES | 2022年 / 28卷 / 12期
关键词：
HOME-RANGE; TBE VIRUS; ROE DEER; SENTINELS; RODENTS; PREVALENCE; AREAS; GOATS; RISK;
D O I：
10.3201/eid2812.220552
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tick-borne encephalitis virus (TBEV) is an emerging pathogen that was first detected in ticks and humans in the Netherlands in 2015 (ticks) and 2016 (humans). To learn more about its distribution and prevalence in the Netherlands, we conducted large-scale surveillance in ticks and rodents during August 2018-September 2020. We tested 320 wild rodents and >46,000 ticks from 48 locations considered to be at high risk for TBEV circulation. We found TBEV RNA in 3 rodents (0.9%) and 7 tick pools (minimum infection rate 0.02%) from 5 geographically distinct foci. Phylogenetic analyses indicated that 3 different variants of the TBEV-Eu subtype circulate in the Netherlands, suggesting multiple independent introductions. Combined with recent human cases outside known TBEV hotspots, our data demonstrate that the distribution of TBEV in the Netherlands is more widespread than previously thought.
引用
收藏
页码：2416 / 2424
页数：9
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