Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients

被引：27

作者：

Sherertz, RJ

Heard, SO

Raad, I

Gentry, L

Bowton, D

Scuderi, P

Hu, J

Carruth, W

Satishchandra, B

Pepe, J

Mosenthal, A

Burke, T

Dupuis, J

机构：

[1] BOWMAN GRAY SCH MED,SECT PULM MED,DEPT MED,WINSTON SALEM,NC 27127

[2] BOWMAN GRAY SCH MED,DEPT ANESTHESIA,WINSTON SALEM,NC 27127

[3] UNIV MASSACHUSETTS,DEPT ANESTHESIA,WORCESTER,MA 01605

[4] ST LUKES EPISCOPAL HOSP,HOUSTON,TX 77030

[5] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED,HOUSTON,TX

[6] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT GYNECOL ONCOL,HOUSTON,TX

[7] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT ANESTHESIOL & CRIT CARE,HOUSTON,TX

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 09期

关键词：

D O I：

10.1128/AAC.40.9.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a randomized, double-blind trial, gamma radiation-sterilized, chlorhexidine-coated triple-lumen catheters were compared with uncoated control catheters for their ability to prevent catheter infection in 254 intensive care unit patients. The chlorhexidine coating was not efficacious, and a rabbit model demonstrated that reduction of chlorhexidine activity by gamma radiation sterilization was the likely explanation for the failure.

引用

页码：1995 / 1997

页数：3

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BACH A, 1994, J ANTIMICROB CHEMOTH, V33, P969

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