Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients

被引：27
作者：
Sherertz, RJ
Heard, SO
Raad, I
Gentry, L
Bowton, D
Scuderi, P
Hu, J
Carruth, W
Satishchandra, B
Pepe, J
Mosenthal, A
Burke, T
Dupuis, J
机构：
[1] BOWMAN GRAY SCH MED,SECT PULM MED,DEPT MED,WINSTON SALEM,NC 27127
[2] BOWMAN GRAY SCH MED,DEPT ANESTHESIA,WINSTON SALEM,NC 27127
[3] UNIV MASSACHUSETTS,DEPT ANESTHESIA,WORCESTER,MA 01605
[4] ST LUKES EPISCOPAL HOSP,HOUSTON,TX 77030
[5] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED,HOUSTON,TX
[6] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT GYNECOL ONCOL,HOUSTON,TX
[7] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT ANESTHESIOL & CRIT CARE,HOUSTON,TX
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 09期
关键词：
D O I：
10.1128/AAC.40.9.1995
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In a randomized, double-blind trial, gamma radiation-sterilized, chlorhexidine-coated triple-lumen catheters were compared with uncoated control catheters for their ability to prevent catheter infection in 254 intensive care unit patients. The chlorhexidine coating was not efficacious, and a rabbit model demonstrated that reduction of chlorhexidine activity by gamma radiation sterilization was the likely explanation for the failure.
引用
收藏
页码：1995 / 1997
页数：3
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