Epigenetic reprogramming rewires transcription during the alternation of generations in Arabidonsis

被引：60

作者：

Borg, Michael ^{[1
]}

Papareddy, Ranjith K. ^{[1
]}

Dombey, Rodolphe ^{[1
]}

Axelsson, Elin ^{[1
]}

Nodine, Michael D. ^{[1
]}

Twell, David ^{[1
,2
]}

Berger, Frederic ^{[1
]}

机构：

[1] Austrian Acad Sci, Gregor Mendel Inst GMI, Vienna, Austria

[2] Univ Leicester, Dept Genet, Leicester, Leics, England

来源：

ELIFE | 2021年 / 10卷

基金：

英国生物技术与生命科学研究理事会; 奥地利科学基金会;

关键词：

MALE GAMETOPHYTE DEVELOPMENT; BODY DNA METHYLATION; GENE-EXPRESSION; TRANSPOSABLE ELEMENTS; REGULATORY SEQUENCES; ACCESSIBLE CHROMATIN; COMPANION CELLS; GENOME DOSAGE; TUBE GROWTH; RNA-SEQ;

D O I：

10.7554/eLife.61894

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alternation between morphologically distinct haploid and diploid life forms is a defining feature of most plant and algal life cycles, yet the underlying molecular mechanisms that govern these transitions remain unclear. Here, we explore the dynamic relationship between chromatin accessibility and epigenetic modifications during life form transitions in Arabidopsis. The diploid-to-haploid life form transition is governed by the loss of H3K9me2 and DNA demethylation of transposon-associated cis-regulatory elements. This event is associated with dramatic changes in chromatin accessibility and transcriptional reprogramming. In contrast, the global loss of H3K27me3 in the haploid form shapes a chromatin accessibility landscape that is poised to reinitiate the transition back to diploid life after fertilisation. Hence, distinct epigenetic reprogramming events rewire transcription through major reorganisation of the regulatory epigenome to guide the alternation of generations in flowering plants.

引用

页码：1 / 66

页数：24

共 108 条

[91] Comprehensive Analysis of Silencing Mutants Reveals Complex Regulation of the Arabidopsis Methylome [J].