Human Papillomavirus-Negative Pharyngeal Cancer

被引：35

作者：

Dillon, Magnus T.

Harrington, Kevin J.

机构：

[1] Inst Canc Res, London SW3 6JB, England

[2] Royal Marsden Hosp, London SW3 6JJ, England

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2015年 / 33卷 / 29期

关键词：

SQUAMOUS-CELL CARCINOMA; LOCALLY ADVANCED HEAD; GROWTH-FACTOR RECEPTOR; QUALITY-OF-LIFE; RANDOMIZED PHASE-II; HPV-POSITIVE HEAD; NECK-CANCER; INDUCTION CHEMOTHERAPY; OROPHARYNGEAL CANCER; RADIATION-THERAPY;

D O I：

10.1200/JCO.2015.60.7804

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human papillomavirus-negative head and neck squamous cell carcinoma (HNSCC) carries a poor prognosis, and despite optimal treatment with chemoradiotherapy to the limit of tolerance, many patients will relapse. A number of methods for intensifying treatment of HNSCC have been investigated, leading to the current standards of care. Novel agents targeting tumor cell and stromal signaling, DNA damage response, and immune system are now reaching clinical trials in combination with chemoradiotherapy. In this review, we discuss the evidence for the current treatment of locally advanced human papillomavirus-negative HNSCC, as well as investigational therapies, such as hypoxia modification, molecular targeting of epidermal growth factor receptor family, vascular endothelial growth factor receptor or DNA damage response proteins in combination with radiation therapy. (C) 2015 by American Society of Clinical Oncology

引用

页码：3251 / +

页数：12

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