THE ROLE OF COMPLEMENT SYSTEM IN HEMATOPOIESIS

被引：0

作者：

Slowik-Zylka, Dorota ^{[1
]}

Poziomkowska-Gesicka, Iwona ^{[1
]}

Mikolajek-Bedner, Wioletta ^{[1
]}

机构：

[1] PAM, Zaklad Fizjol, Katedra Fizjopatol, PL-70111 Szczecin, Poland

来源：

POSTEPY BIOLOGII KOMORKI | 2009年 / 36卷 / 02期

关键词：

stromal derived factor-1 (SDF-1); hematopoiesis; CXCR4; receptor; complement system; CHEMOKINE RECEPTOR CXCR4; STEM-CELL MOBILIZATION; HOMING-RELATED RESPONSES; HUMAN CD34(+) CELLS; BONE-MARROW; STEM/PROGENITOR CELLS; COMPONENT C3; FACTOR-I; PERIPHERAL-BLOOD; ALTERNATIVE PATHWAY;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This review presents the experimental data indicating that complement system plays an important, however, up to now underestimated role in the regulation of hematopoiesis. The cleavage fragments of the third complement component (C3) regulate the response of early hematopoietic cells to an SDF-1 gradient, which is the main chemoattractant for stern cells. Complement system is activated in bone marrow both during myeloablative conditioning for hematopoietic transplantation as well as during pharmacological mobilization of stem cells. Therefore modulation of complement activation may lead to new strategies to accelerate engraftment of stern cells or to increase their mobilization into peripheral blood.

引用

页码：279 / 294

页数：16

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