LncRNAs in Ovarian Cancer Progression, Metastasis, and Main Pathways: ceRNA and Alternative Mechanisms

被引：192
作者：
Braga, Eleonora A. [1 ,2 ]
Fridman, Marina, V [3 ]
Moscovtsev, Alexey A. [1 ]
Filippova, Elena A. [1 ]
Dmitriev, Alexey A. [4 ]
Kushlinskii, Nikolay E. [5 ]
机构：
[1] Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
[2] Res Ctr Med Genet, Moscow 115522, Russia
[3] Russian Acad Sci, Vavilov Inst Gen Genet, Moscow 119991, Russia
[4] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia
[5] NN Blokhin Natl Med Res Ctr Oncol, Moscow 115478, Russia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 22期
基金：
俄罗斯科学基金会;
关键词：
ovarian cancer; long non-coding RNAs; competitive endogenous RNAs; miRNAs; oncogenic and suppressive lncRNAs; metastasis; signaling pathways; LONG NONCODING RNA; PROMOTES CELL-PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; COMPETING ENDOGENOUS RNA; PACLITAXEL RESISTANCE; REGULATES PROLIFERATION; POOR-PROGNOSIS; ONCOGENIC ROLE; INVASION; MIGRATION;
D O I：
10.3390/ijms21228855
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ovarian cancer (OvCa) develops asymptomatically until it reaches the advanced stages with metastasis, chemoresistance, and poor prognosis. Our review focuses on the analysis of regulatory long non-coding RNAs (lncRNAs) competing with protein-coding mRNAs for binding to miRNAs according to the model of competitive endogenous RNA (ceRNA) in OvCa. Analysis of publications showed that most lncRNAs acting as ceRNAs participate in OvCa progression: migration, invasion, epithelial-mesenchymal transition (EMT), and metastasis. More than 30 lncRNAs turned out to be predictors of survival and/or response to therapy in patients with OvCa. For a number of oncogenic (CCAT1, HOTAIR, NEAT1, and TUG1 among others) and some suppressive lncRNAs, several lncRNA/miRNA/mRNA axes were identified, which revealed various functions for each of them. Our review also considers examples of alternative mechanisms of actions for lncRNAs besides being ceRNAs, including binding directly to mRNA or protein, and some of them (DANCR, GAS5, MALAT1, and UCA1 among others) act by both mechanisms depending on the target protein. A systematic analysis based on the data from literature and Panther or KEGG (Kyoto Encyclopedia of Genes and Genomes) databases showed that a significant part of lncRNAs affects the key pathways involved in OvCa metastasis, EMT, and chemoresistance.
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页码：1 / 44
页数：44
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