Minute Effects of Sex on the Aging Brain: A Multisample Magnetic Resonance Imaging Study of Healthy Aging and Alzheimer's Disease

被引：101

作者：

Fjell, Anders M. ^{[1
,3
]}

Westlye, Lars T. ^{[1
]}

Amlien, Inge ^{[1
]}

Espeseth, Thomas ^{[1
]}

Reinvang, Ivar ^{[1
]}

Raz, Naftali ^{[4
,5
]}

Agartz, Ingrid ^{[2
,6
,7
]}

Salat, David H. ^{[8
]}

Greve, Doug N. ^{[8
]}

Fischl, Bruce ^{[8
,9
]}

Dale, Anders M. ^{[10
,11
,12
]}

Walhovd, Kristine B. ^{[1
,3
]}

机构：

[1] Univ Oslo, Dept Psychol, Ctr Study Human Cognit, N-0317 Oslo, Norway

[2] Univ Oslo, Dept Psychiat, N-0317 Oslo, Norway

[3] Ullevaal Univ Hosp, Dept Neuropsychiat, N-0317 Oslo, Norway

[4] Wayne State Univ, Dept Psychol, Detroit, MI 48202 USA

[5] Wayne State Univ, Inst Gerontol, Detroit, MI 48202 USA

[6] Diakonhjemmet Hosp, Dept Psychiat Res, N-0319 Oslo, Norway

[7] Karolinska Hosp & Inst, Psychiat Sect, Dept Clin Neurosci, S-17176 Stockholm, Sweden

[8] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Athinoula A Martinos Ctr,Dept Radiol, Charlestown, MA 02129 USA

[9] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA

[10] Univ Calif San Diego, Multimodal Imaging Lab, La Jolla, CA 92093 USA

[11] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA

[12] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

来源：

JOURNAL OF NEUROSCIENCE | 2009年 / 29卷 / 27期

关键词：

MILD COGNITIVE IMPAIRMENT; SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX; ADULT HUMAN BRAIN; CORTICAL THICKNESS; WHITE-MATTER; GRAY-MATTER; VOLUME DECLINE; YOUNG ADULTS; GREY-MATTER;

D O I：

10.1523/JNEUROSCI.0115-09.2009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Age is associated with substantial macrostructural brain changes. While some recent magnetic resonance imaging studies have reported larger age effects in men than women, others find no sex differences. As brain morphometry is a potentially important tool in diagnosis and monitoring of age-related neurological diseases, e.g., Alzheimer's disease (AD), it is important to know whether sex influences brain aging. We analyzed cross-sectional magnetic resonance scans from 1143 healthy participants from seven subsamples provided by four independent research groups. In addition, 96 patients with mild AD were included. Estimates of cortical thickness continuously across the brain surface, as well as volume of 17 subcortical structures, were obtained by use of automated segmentation tools (FreeSurfer). In the healthy participants, no differences in aging slopes between women and men were found in any part of the cortex. Pallidum corrected for intracranial volume showed slightly higher age correlations for men. The analyses were repeated in each of the seven subsamples, and the lack of age x sex interactions was largely replicated. Analyses of the AD sample showed no interactions between sex and age for any brain region. We conclude that sex has negligible effects on the age slope of brain volumes both in healthy participants and in AD.

引用

页码：8774 / 8783

页数：10

共 76 条

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