Self-assembly of dextran - b - deoxycholic acid polyester copolymers: Copolymer composition and self-assembly procedure tune the aggregate size and morphology

Self-assembly potential of new amphiphilic block copolymers containing dextran (Mn 4500, 8000, 15,000) and a semi-rigid deoxycholic acid-oligoethyleneglycol polyester (Mn 2500-8800, 2 or 4 ethyleneglycol units), was evaluated as a function of copolymer composition and self-assembly procedure, using dynamic light scattering and transmission electron microscopy. Addition of copolymer solution to water provided small star-like micelles (similar to 100 nm), while addition of water to copolymer solution led to various morphologies and sizes (60-600 nm), depending on polymer composition. Worm-like micelles were obtained from a copolymer containing dextran with Mn 4500 and 66 wt% polyester, and vesicles were formed by copolymers prepared from dextran with Mn 8000 and containing 46 wt% polyester. Presence of a longer oligoethyleneglycol decreased the size of micelles and vesicles due to an enhanced flexibility of the polyester hydrophobic block. The results allow the selection of the most appropriate parameters to obtain the desired aggregate characteristics.