NEDD4 E3 ligase: Functions and mechanism in human cancer

被引：83

作者：

Wang, Zhi-Wei ^{[1
,2
]}

Hu, Xiaoli ^{[3
]}

Ye, Miaomiao ^{[3
]}

Lin, Min ^{[3
]}

Chu, Man ^{[1
]}

Shen, Xian ^{[4
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 2, Ctr Sci Res, Wenzhou 325027, Zhejiang, Peoples R China

[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA

[3] Wenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325027, Zhejiang, Peoples R China

[4] Wenzhou Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, Wenzhou 325027, Zhejiang, Peoples R China

来源：

SEMINARS IN CANCER BIOLOGY | 2020年 / 67卷

关键词：

Ubiquitination; E3; ligases; NEDD4; Cancer; Therapy; UBIQUITIN-PROTEASOME SYSTEM; UP-REGULATION; DEPENDENT UBIQUITINATION; CELLULAR-TRANSFORMATION; MESENCHYMAL TRANSITION; MEDIATED DEGRADATION; NEGATIVE REGULATOR; TENSIN HOMOLOG; SMALL-MOLECULE; HECT FAMILY;

D O I：

10.1016/j.semcancer.2020.03.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A growing amount of evidence indicates that the neuronally expressed developmentally downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a variety of cellular processes via the ubiquitination-mediated degradation of multiple substrates. The abnormal regulation of NEDD4 protein has been implicated in cancer development and progression. In this review article, we briefly delineate the downstream substrates and upstream regulators of NEDD4, which are involved in carcinogenesis. Moreover, we succinctly elucidate the functions of NEDD4 protein in tumorigenesis and progression, including cell proliferation, apoptosis, cell cycle, migration, invasion, epithelial mesenchymal transition (EMT), cancer stem cells, and drug resistance. The findings regarding NEDD4 functions are further supported by knockout mouse models and human tumor tissue studies. This review could provide a promising and optimum anticancer therapeutic strategy via targeting the NEDD4 protein.

引用

页码：92 / 101

页数：10

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