Genetics of Cardiovascular Development

被引:8
作者
Chaudhry, Bill [1 ]
Ramsbottom, Simon [1 ]
Henderson, Deborah J. [1 ]
机构
[1] Newcastle Univ, Inst Med Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源
GENETICS OF CARDIOVASCULAR DISEASE | 2014年 / 124卷
关键词
2ND HEART FIELD; CARDIAC PROGENITOR CELLS; NEURAL CREST CELLS; RETINOIC ACID; OUTFLOW TRACT; CONDUCTION SYSTEM; BETA-CATENIN; VENOUS POLE; BOX GENE; EXPRESSION;
D O I
10.1016/B978-0-12-386930-2.00002-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Structural malformations of the heart are the commonest abnormalities found at the time of birth and the incidence is higher in fetuses that are lost during the first trimester. Although the form of the heart has been studied for centuries, it is in the past decades that the genetic pathways that control heart development have been unraveled. Recently, the concept of the second heart field, a population of multipotent cardiac cells that augment the initial simple heart tube, has clarified the development of the heart. Understanding how the second heart field is used in morphogenesis and how genes interact in a subtle and more complex way is moving us closer to understanding how the normal heart forms and why abnormalities occur. In this chapter, we present a description of the morphological processes that create the formed postnatal human heart and emphasize key genetic pathways and genes that control these aspects. Where possible, these are also linked to the common patterns of human cardiac malformation. Undoubtedly, the details will refine or change with further research but emphasis has been placed on areas of greatest certainty and the presentation designed to promote a general understanding.
引用
收藏
页码:19 / 41
页数:23
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