Biochemical Markers of Bone Metabolism in Breast Cancer

被引：7

作者：

Lyubimova, N. V. ^{[1
]}

Kozharskaya, G. V. ^{[1
]}

Portnoi, S. M. ^{[1
]}

Kushlinskii, N. E. ^{[1
]}

机构：

[1] Russian Acad Med Sci, NN Blokhin Russian Canc Res Ctr, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 06期

关键词：

biochemical markers; bone metastases; breast cancer; METASTASES;

D O I：

10.1007/s10517-014-2663-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The relationship between biochemical markers of bone resorption (C-terminal telopeptide, deoxypyridinoline, tartrate-resistant acid phosphatase 5b) and osteosynthesis (bone alkaline phosphatase) and clinical manifestations of bone metastases were studied in 239 patients with breast cancer with and without signs of bone involvement. High levels of C-terminal telopeptide and bone alkaline phosphatase were associated with poor prognosis: more severe skeletal complications and lesser survival values. These biochemical markers can be used for prognosis and optimization of therapy for bone metastases in patients with breast cancer.

引用

页码：769 / 772

页数：4

共 13 条

[1] Baseline serum NTx levels are prognostic in metastatic breast cancer patients with bone-only metastasis [J].

Ali, SM ;

Demers, LM ;

Leitzel, K ;

Harvey, HA ;

Clemens, D ;

Mallinak, N ;

Engle, L ;

Chinchilli, V ;

Costa, L ;

Brady, C ;

Seaman, J ;

Lipton, A .

ANNALS OF ONCOLOGY, 2004, 15 (03) :455-459

[2] Bone resorption predicts for skeletal complications in metastatic bone disease [J].

Brown, JE ;

Thomson, CS ;

Ellis, SP ;

Gutcher, SA ;

Purohit, OP ;

Coleman, RE .

BRITISH JOURNAL OF CANCER, 2003, 89 (11) :2031-2037

[3]

Chirgwin JM, 2000, CRIT REV EUKAR GENE, V10, P159

[4] Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid [J].

Coleman, RE ;

Major, P ;

Lipton, A ;

Brown, JE ;

Lee, KA ;

Smith, M ;

Saad, F ;

Zheng, M ;

Hei, YJ ;

Seaman, J ;

Cook, R .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (22) :4925-4935

[5] Prospective evaluation of the peptide-bound collagen type I cross-links N-telopeptide and C-telopeptide in predicting bone metastases status [J].

Costa, L ;

Demers, LM ;

Gouveia-Oliveira, A ;

Schaller, J ;

Costa, EB ;

de Moura, MC ;

Lipton, A .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (03) :850-856

[6] Biochemical markers and skeletal metastases [J].

Demers, LM ;

Costa, L ;

Lipton, A .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2003, (415) :S138-S147

[7]

Izumi M, 2001, CANCER, V91, P1487, DOI 10.1002/1097-0142(20010415)91:8<1487::AID-CNCR1156>3.0.CO

[8]

2-2

[9]

Luttner D., 2003, ANTICANCER RES, V23, P1017

[10]

Lyubimova N. V., 2006, SIBIRSK ONKOL ZH, P116

← 1 2 →