Hepatitis B virus pre-S region: Clinical implications and applications

被引：8
作者：
Sun, Huizhen [1 ,2 ,3 ]
Chang, Le [1 ,2 ]
Yan, Ying [1 ,2 ]
Wang, Lunan [1 ,2 ,3 ]
机构：
[1] Chinese Acad Med Sci, Beijing Hosp, Natl Ctr Clin Labs, Natl Ctr Gerontol Inst Geriatr Med, Beijing, Peoples R China
[2] Beijing Hosp, Beijing Engn Res Ctr Lab Med, Beijing, Peoples R China
[3] Chinese Acad Med Sci, Peking Union Med Coll, Grad Sch, Beijing, Peoples R China
来源：
REVIEWS IN MEDICAL VIROLOGY | 2021年 / 31卷 / 04期
关键词：
hepatitis B virus (HBV); pre‐ S mutants; occult HBV infection; FIBROSING CHOLESTATIC HEPATITIS; LIVER-TRANSPLANT RECIPIENTS; CLOSED CIRCULAR DNA; SURFACE-ANTIGEN; HEPATOCELLULAR-CARCINOMA; IMMUNE-RESPONSE; GENE-DELIVERY; T-CELL; TRANSMEMBRANE TOPOLOGY; PEPTIDE INHIBITORS;
D O I：
10.1002/rmv.2201
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Hepatitis B virus (HBV) infection is a major threat to global public health, which can result in many acute and chronic liver diseases. HBV, a member of the family Hepadnaviridae, is a small enveloped DNA virus containing a circular genome of 3.2 kb. Located upstream of the S-open-reading frame of the HBV genome is the pre-S region, which is vital to the viral life cycle. The pre-S region has high variability and many mutations in the pre-S region are associated with several liver diseases, such as fulminant hepatitis (FH), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). In addition, the pre-S region has been applied in the development of several pre-S-based materials and systems to prevent or treat HBV infection. In conclusion, the pre-S region plays an essential role in the occurrence, diagnosis, and treatment of HBV-related liver diseases, which may provide a novel perspective for the study of HBV infection and relevant diseases.
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页数：14
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