Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi

被引：19

作者：

Zhu, Nan-Lin ^{[1
,3
]}

Tang, Chunping ^{[1
,4
]}

Xu, Chenghui ^{[2
]}

Ke, Chang-Qiang ^{[1
,4
]}

Lin, Ge ^{[4
]}

Jenis, Janar ^{[5
]}

Yao, Sheng ^{[1
,4
]}

Liu, Hongchun ^{[2
]}

Ye, Yang ^{[1
,3
,4
,6
,7
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[3] Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China

[4] SIMM CUHK Joint Res Lab Promoting Globalizat Trad, Shanghai 201203, Peoples R China

[5] Al Farabi Kazakh Natl Univ, Res Ctr Med Plants, Al Farabi Ave 71, Alma Ata 050040, Kazakhstan

[6] Guangxi Normal Univ, Collaborat Innovat Ctr Southwest Ethn Med, Guiling 541001, Peoples R China

[7] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 04期

基金：

中国国家自然科学基金;

关键词：

STRUCTURE ELUCIDATION;

D O I：

10.1021/acs.jnatprod.8b01004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten new sesquiterpene lactones, carlipsines A J (1-10), and 12 known analogues (11-22) were isolated from the whole plant of Carpesium lipskyi. Their structures were elucidated by using 1D and 2D NMR and HRESIMS analyses, and their absolute configurations were confirmed by X-ray diffraction studies. All compounds were identified as germacranolides with diverse substructural features. Compounds 1-4 are 2,5-hemiacetal-linked germacranolides. Compounds 5 and 6 possess a 1,2-epoxy moiety. Compounds 7 and 8 represent unusual 1,5-hemiacetal-linked germacranolides. Compounds 9 and 10 contain a tetrahydrofuran unit with the oxygen atom bridging C-1 and C-8. Compounds 6, 7, 8, 19, 20, 21, and 22 showed cytotoxicity against HL-60 and A-549 cell lines with IC50 values ranging from 2.8 to 10.3 mu M.

引用

页码：919 / 927

页数：9

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