Influence of cyclodextrin on the UCST- and LCST-behavior of poly(2-methacrylamido-caprolactam)-co-(N, N-dimethylacrylamide)

被引：22

作者：

Burkhart, Alexander ^{[1
]}

Ritter, Helmut ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Organ Chem & Macromol Chem, D-40225 Dusseldorf, Germany

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 10卷

关键词：

cyclodextrin; LCST; lysine; 2-methacrylamido-caprolactam; UCST; N-ISOPROPYLACRYLAMIDE; PHASE-BEHAVIOR; POLYMERS; WATER; TRANSITIONS; COPOLYMERS; DELIVERY;

D O I：

10.3762/bjoc.10.203

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The monomer 2-methacrylamido-caprolactam (4) was synthesized from methacryloyl chloride (3) and racemic a-amino-e-caprolactam (2). Copolymerization of 4 with N, N-dimethylacrylamide (5) was carried out by a free-radical mechanism using 2,2'-azobis(2-methylpropionitrile) (AIBN) as an initiator. The new copolymers show a lower critical solution temperature (LCST) in water and an upper critical solution temperature (UCST) in ethanol, 1-propanol, and 1-butanol. The solubility properties of the copolymers can be influenced significantly by the addition of randomly methylated beta-cyclodextrin (CD). The complexation of the copolymers with CD, was confirmed by the use of ROESY-NMR-spectroscopy.

引用

页码：1951 / 1958

页数：8

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