Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma

被引：134
作者：
Ribatti, D.
Nico, B.
Vacca, A.
机构：
[1] Univ Bari, Sch Med, Dept Human Anat & Histol, Policlin, I-70124 Bari, Italy
[2] Univ Bari, Sch Med, Dept Internal Med & Clin Oncol, I-70124 Bari, Italy
来源：
ONCOGENE | 2006年 / 25卷 / 31期
关键词：
angiogenesis; bone marrow; microenvironment; multiple myeloma;
D O I：
10.1038/sj.onc.1209456
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion and metastasis through its provision of survival signals, secretion of growth and pro-angiogenic factors, and direct adhesion molecule interactions. This review examines its importance in the induction of an angiogenic response in multiple myeloma (MM). The encouraging results of preclinical and clinical trials in which MM has been treated by targeting the tumor microenvironment are also discussed.
引用
收藏
页码：4257 / 4266
页数：10
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