Cholinergic imbalance in lumbar spinal cord of a rat model of multiple sclerosis

被引：3

作者：

Liu, Chunling ^{[1
,2
]}

Liu, Hui ^{[1
]}

Jin, Hongjun ^{[1
]}

Yue, Xuyi ^{[1
]}

Luo, Zonghua ^{[1
]}

Tu, Zhude ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA

[2] Zhengzhou Univ, Affiliated Hosp 2, Dept Neurol, 2 Jingba Rd, Zhengzhou 450014, Henan, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2018年 / 318卷

关键词：

Vesicular acetylcholine transporter; Experimental autoimmune encephalomyelitis; Neuroinflammation; VESICULAR ACETYLCHOLINE TRANSPORTER; CENTRAL-NERVOUS-SYSTEM; INFLAMMATION; EXPRESSION; ACTIVATION; DISEASE;

D O I：

10.1016/j.jneuroim.2018.01.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cholinergic dysfunction in the central nervous system is an important characteristic of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). By using a rat EAE model, upregulation of vesicular acetylcholine transporter (VAChT) level in the EAE rat lumbar spinal cord was detected by western blot and immunostaining, and was associated with lymphocyte filtration and glial activation. Ex vivo and in vitro autoradiography studies with [F-18]VAT, a VAChT-specific radioligand, also revealed increased tracer uptake in EAE rat lumbar spinal cord compared with shams. These studies on VAChT expression suggest central cholinergic imbalance during EAE progression.

引用

页码：29 / 35

页数：7

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