The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure

被引：46

作者：

Barquera, Rodrigo ^{[1
,2
]}

Iraiz Hernandez-Zaragoza, Diana ^{[2
,3
]}

Bravo-Acevedo, Alicia ^{[4
]}

Arrieta-Bolanos, Esteban ^{[5
]}

Clayton, Stephen ^{[1
]}

Acuna-Alonzo, Victor ^{[2
]}

Cesar Martinez-Alvarez, Julio ^{[6
]}

Lopez-Gil, Concepcion ^{[7
]}

Adalid-Sainz, Carmen ^{[8
]}

del Rosario Vega-Martinez, Maria ^{[9
]}

Escobedo-Ruiz, Araceli ^{[10
]}

Dolores Juarez-Cortes, Eva ^{[11
]}

Immel, Alexander ^{[1
,12
]}

Pacheco-Ubaldo, Hanna ^{[2
]}

Gonzalez-Medina, Liliana ^{[2
]}

Lona-Sanchez, Abraham ^{[2
]}

Lara-Riegos, Julio ^{[13
]}

Guadalupe de Jesus Sanchez-Fernandez, Maria ^{[14
,15
]}

Diaz-Lopez, Rosario ^{[16
]}

Ulises Guizar-Lopez, Gregorio ^{[16
]}

Elizabeth Medina-Escobedo, Carolina ^{[17
]}

Araceli Arrazola-Garcia, Maria ^{[6
]}

Daniel Montiel-Hernandez, Gustavo ^{[18
]}

Hernandez-Hernandez, Ofelia ^{[3
]}

del Rocio Ramos-de la Cruz, Flor ^{[7
]}

Juarez-Nicolas, Francisco ^{[19
]}

Arturo Pantoja-Torres, Jorge ^{[20
]}

Jesus Rodriguez-Munguia, Tirzo ^{[21
]}

Juarez-Barreto, Vicencio ^{[22
]}

Delgado-Aguirre, Hector ^{[8
]}

Berenice Escutia-Gonzalez, Ariadna ^{[19
]}

Gone-Vazquez, Isis ^{[10
]}

Benitez-Arvizu, Gamaliel ^{[6
]}

Paulina Arellano-Prado, Francia ^{[23
]}

Eduardo Garcia-Arias, Victor ^{[23
]}

Estefania Rodriguez-Lopez, Marla ^{[23
]}

Mendez-Mani, Patricia ^{[7
]}

Garcia-Alvarez, Raquel ^{[24
]}

del Rocio Gonzalez-Martinez, Marisela ^{[25
]}

Aquino-Rubio, Guadalupe ^{[21
]}

Escareno-Montiel, Nestor ^{[26
]}

Veronica Vazquez-Castillo, Tannya ^{[27
]}

Guadalupe Uribe-Duarte, Maria ^{[28
]}

de Jesus Ruiz-Corral, Maria ^{[28
]}

Ortega-Yanez, Andrea ^{[29
]}

Bernal-Felipe, Natalia ^{[18
]}

Gomez-Navarro, Benjamin ^{[30
]}

Jerico Arriaga-Perea, Agustin ^{[11
]}

Martinez-Bezies, Virginia ^{[19
]}

Maria Macias-Medrano, Rosa ^{[11
]}

机构：

[1] Max Planck Inst Sci Human Hist MPI SHH, Dept Archaeogenet, Jena, Germany

[2] Escuela Nacl Antropol & Hist ENAH, Mol Genet Lab, Mexico City, DF, Mexico

[3] Tecn Genet Aplicadas Clin TGAC, Immunogenet Unit, Mexico City, DF, Mexico

[4] Inst Mexicano Seguro Social IMSS, UMAE Hosp Gineco Obstet 4 Luis Castelazo Ayala, Blood Bank, Mexico City, DF, Mexico

[5] Univ Hosp Essen, Inst Expt Cellular Therapy, Essen, Germany

[6] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Siglo XXI, Hosp Especialidades, HLA Lab,Cent Blood Bank,Unidad Med Alta Especiali, Mexico City, DF, Mexico

[7] Inst Mexicano Seguro Social IMSS, Histocompatibil Lab, Unidad Med Alta Especialidad UMAE 6, Puebla, Mexico

[8] Inst Mexicano Seguro Social IMSS, Lab Histocompatibil, Unidad Med Alta Especialidad UMAE 71, Torreon, Coahuila, Mexico

[9] Hosp Cent Sur Alta Especialidad, Mol Biol & Histocompatibil Lab, Petr Mexicanos PEMEX, Mexico City, DF, Mexico

[10] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Hosp Especialidades, Histocompatibil Lab, Guadalajara, Jalisco, Mexico

[11] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl La Raza, Histocompatibil Lab, Cent Blood Bank, Mexico City, DF, Mexico

[12] Univ Kiel, Univ Hosp, Inst Clin Mol Biol IKMB, Schleswig Holstein, Germany

[13] Univ Autonoma Yucatan UADY, Chem Fac, Merida, Yucatan, Mexico

[14] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Dept Nephrol, Guadalajara, Jalisco, Mexico

[15] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Transplantat Unit, Guadalajara, Jalisco, Mexico

[16] Secretaria Def Nacl SEDENA, Mol Biol Lab, Hosp Cent Mil, Mexico City, DF, Mexico

[17] Inst Mexicano Seguro Social IMSS, Unit Res & Educ Hlth, Unidad Med Alta Especialidad UMAE 10, Merida, Yucatan, Mexico

[18] Escuela Nacl Antropol & Hist ENAH, Mexico City, DF, Mexico

[19] Inst Nacl Pediat INP, Mol Immunogenet Lab, Mexico City, DF, Mexico

[20] Inst Mexicano Seguro Social IMSS, Immunol Div, Unidad Med Alta Especialidad UMAE 1, Guanajuato, Mexico

[21] Hosp Gen Norberto Trevino Zapata, Direcc Serv Salud Tamaulipas, Mol Biol Lab, Ciudad Victoria, Tamaulipas, Mexico

[22] Hosp Infantil Mexico Dr Federico Gomez, Blood Bank, Mexico City, DF, Mexico

[23] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Pediat Hosp, Guadalajara, Jalisco, Mexico

[24] Inst Nacl Pediat INP, Res Unit, Pharmacol Lab, Mexico City, DF, Mexico

[25] Univ Autonoma Coahuila, Fac Med, Microbiol Dept, Torreon, Coahuila, Mexico

[26] Inst Mexicano Seguro Social IMSS, Dept Transplantat, Unidad Med Alta Especialidad UMAE 71, Torreon, Coahuila, Mexico

[27] Dept Mol Biol, Labs Diagnost, Villahermosa, Tabasco, Mexico

[28] Inst Mexicano Seguro Social IMSS, Clin Lab, Unidad Med Alta Especialidad UMAE 2, Obregon, Sonora, Mexico

[29] Univ Nacl Autonoma Mexico, Inst Biotecnol IBT, Dept Dev Genet & Mol Physiol, Cuernavaca, Morelos, Mexico

[30] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Cent Off Nephrol, Guadalajara, Jalisco, Mexico

[31] Inst Mexicano Seguro Social IMSS, Hlth Res Div, Unidad Med Alta Especialidad UMAE 71, Torreon, Coahuila, Mexico

[32] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl Occidente CMNO, Cent Off Transplantat, Guadalajara, Jalisco, Mexico

[33] Inst Mexicano Seguro Social IMSS, Direct Hlth Educ & Res, Unidad Med Alta Especialidad UMAE 71, Torreon, Coahuila, Mexico

[34] Inst Mexicano Seguro Social IMSS, Med Infrastruct Planning Comm, Mexico City, DF, Mexico

[35] Univ Fed Rio Grande do Sul, Dept Genet, Porto Alegre, RS, Brazil

[36] Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Labs Invest & Desarrollo, Lima, Peru

[37] Univ Antioquia, Genet Mol GENMOL, Medellin, Colombia

[38] Univ Chile, Fac Med, ICBM, Programa Genet Humana, Santiago, Chile

[39] Univ Tarapaca, Inst Alta Invest, Arica, Chile

[40] Consejo Nacl Invest Cient & Tecn, Inst Patagon Ciencias Sociales & Humanas, Ctr Nacl Patagon, Puerto Madryn, Argentina

[41] Fudan Univ, Minist Educ, Key Lab Contemporary Anthropol, Shanghai, Peoples R China

[42] Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China

[43] Aix Marseille Univ, ADES, EFS, CNRS, Marseille, France

[44] Univ Nacl Autonoma Mexico, Fac Quim, Unidad Genom Poblac Aplicada Salud, Mexico City, DF, Mexico

[45] Inst Nacl Med Genom, Mexico City, DF, Mexico

[46] Inst Nacl Med Genom INMEGEN, Dept Computat Genom, Mexico City, DF, Mexico

[47] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Lab Immunobiol & Genet, Mexico City, DF, Mexico

[48] Tecnol Monterrey, Escuela Med & Ciencias Salud, Mexico City, DF, Mexico

[49] Dana Farber Canc Inst, Dept Canc Immunol & Virol, Boston, MA 02115 USA

[50] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl La Raza, Infectol Hosp, Immunol & Infectol Res Unit, Mexico City, DF, Mexico

来源：

HUMAN IMMUNOLOGY | 2020年 / 81卷 / 09期

基金：

英国生物技术与生命科学研究理事会;

关键词：

HLA; Immunogenetics; Population genetics; Genetic substructure; Admixture; Latin American populations; Mexico; ASHI MINORITY WORKSHOPS; INDUCED LIVER-INJURY; CLASS-II HAPLOTYPES; ANTIGEN CLASS-I; ETHNIC-GROUPS; ABACAVIR HYPERSENSITIVITY; AMERINDIAN POPULATIONS; BALANCING SELECTION; ALLELE FREQUENCIES; CAYAPA INDIANS;

D O I：

10.1016/j.humimm.2020.06.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the presence of 4268 unique HLA extended haplotypes across Mexico and find that the ten most frequent (HF > 1%) HLA haplotypes with significant linkage disequilibrium (Delta'>= 0.1) in Mexico (accounting for 20% of the haplotypic diversity of the country) are of primarily Native American ancestry (A*02 similar to B*39 similar to DRB1*04 similar to DQB1*03:02, A*02 similar to B*35 similar to DRB1*08 similar to DQB1*04, A*68 similar to B*39 similar to DRB1*04 similar to DQB1*03:02, A*02 similar to B*35 similar to DRB1*04 similar to DQB1*03:02, A*24 similar to B*39 similar to DRB1*14 similar to DQB1*03:01, A*24 similar to B*35 similar to DRB1*04 similar to DQB1*03:02, A*24 similar to B*39 similar to DRB1*04 similar to DQB1*03:02, A*02 similar to B*40:02 similar to DRB1*04 similar to DQB1*03:02, A*68 similar to B*35 similar to DRB1*04 similar to DQB1*03:02, A*02 similar to B*15:01 similar to DRB1*04 similar to DQB1*03:02). Admixture estimates obtained by a maximum likelihood method using HLA-A/-B/-DRB1 as genetic estimators revealed that the main genetic components in Mexico as a whole are Native American (ranging from 37.8% in the northern part of the country to 81.5% in the southeastern region) and European (ranging from 11.5% in the southeast to 62.6% in northern Mexico). African admixture ranged from 0.0 to 12.7% not following any specific pattern. We were able to detect three major immunogenetic clusters correlating with genetic diversity and differential admixture within Mexico: North, Central and Southeast, which is in accordance with previous reports using genome-wide data. Our findings provide insights into the population immunogenetic substructure of the whole country and add to the knowledge of mixed ancestry Latin American population genetics, important for disease association studies, detection of demographic signatures on population variation and improved allocation of public health resources.

引用

页码：461 / 474

页数：14

共 178 条

[1] Genetic diversity of HLA system in three populations from Coahuila, Mexico: Torreon, Saltillo and rural Coahuila [J].

Adalid-Sainz, Carmen ;

Barquera, Rodrigo ;

Crawford, Michael H. ;

Lona-Sanchez, Abraham ;

Clayton, Stephen ;

Arrieta-Bolanos, Esteban ;

Delgado-Aguirre, Hector ;

Gonzalez-Medina, Liliana ;

Pacheco-Ubaldo, Hanna ;

Iraiz Hernandez-Zaragoza, Diana ;

Bravo-Acevedo, Alicia ;

Escareno-Montiel, Nestor ;

Moran-Martinez, Javier ;

del Rocio Gonzalez-Martinez, Marisela ;

Jaramillo-Rodriguez, Yolanda ;

Salgado-Adame, Antonio ;

Juarez-de la Cruz, Federico ;

Zuniga, Joaquin ;

Yunis, Edmond J. ;

Bekker-Mendez, Carolina ;

Granados, Julio .

HUMAN IMMUNOLOGY, 2020, 81 (09) :492-495

[2] HLA genes in Cubans and the detection of Amerindian alleles [J].

Alegre, Roberto ;

Moscoso, Juan ;

Martinez-Laso, Jorge ;

Martin-Villa, Manuel ;

Suarez, Jose ;

Moreno, Almudena ;

Serrano-Vela, Juan I. ;

Vargas-Alarcon, Gilberto ;

Pacheco, Remedios ;

Arnaiz-Villena, Antonio .

MOLECULAR IMMUNOLOGY, 2007, 44 (09) :2426-2435

[3] In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers [J].

Alfirevic, Ana ;

Gonzalez-Galarza, Faviel ;

Bell, Catherine ;

Martinsson, Klara ;

Platt, Vivien ;

Bretland, Giovanna ;

Evely, Jane ;

Lichtenfels, Maike ;

Cederbrant, Karin ;

French, Neil ;

Naisbitt, Dean ;

Park, B. Kevin ;

Jones, Andrew R. ;

Pirmohamed, Munir .

GENOME MEDICINE, 2012, 4

[4] HLA-A, -B and-DRB1 allele frequencies in the Bangladeshi population [J].

Ali, Md. Eunus ;

Ahmed, M. U. ;

Alam, S. ;

Rahman, Md. Hafizur .

TISSUE ANTIGENS, 2008, 72 (02) :115-119

[5]

American Board of Histocompatibility and Immunogenetics, 2009, ABHI CAND HDB

[6] HLA-A*31:01 and HLA-B*15:02 as Genetic Markers for Carbamazepine Hypersensitivity in Children [J].

Amstutz, U. ;

Ross, C. J. D. ;

Castro-Pastrana, L. I. ;

Rieder, M. J. ;

Shear, N. H. ;

Hayden, M. R. ;

Carleton, B. C. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2013, 94 (01) :142-149

[7]

[Anonymous], 2013, DIVERSIDAD HAPLOTIPO

[8] Origin of Aymaras from Bolivia and their relationship with other Amerindians according to HLA genes [J].

Arnaiz-Villena, A ;

Siles, N ;

Moscoso, J ;

Zamora, J ;

Serrano-Vela, JI ;

Gomez-Casado, E ;

Castro, MJ ;

Martinez-Laso, J .

TISSUE ANTIGENS, 2005, 65 (04) :379-390

[9] HLA genes in Uros from Titikaka Lake, Peru: origin and relationship with other Amerindians and worldwide populations [J].

Arnaiz-Villena, A. ;

Gonzalez-Alcos, V. ;

Serrano-Vela, J. I. ;

Reguera, R. ;

Barbolla, L. ;

Parga-Lozano, C. ;

Gomez-Prieto, P. ;

Abd-El-Fatah-Khalil, S. ;

Moscoso, J. .

INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2009, 36 (03) :159-167

[10] HLA genes in Mexican Mazatecans, the peopling of the Americas and the uniqueness of Amerindians [J].

Arnaiz-Villena, A ;

Vargas-Alarcón, G ;

Granados, J ;

Gómez-Casado, E ;

Longas, J ;

Gonzales-Hevilla, M ;

Zuñiga, J ;

Salgado, N ;

Hernández-Pacheco, G ;

Guillen, J ;

Martinez-Laso, J .

TISSUE ANTIGENS, 2000, 56 (05) :405-416

← 1 2 3 4 5 6 7 8 9 10 →