1,2,4-Triazoles as Important Antibacterial Agents

被引：136
作者：
Strzelecka, Malgorzata [1 ]
Swiatek, Piotr [1 ]
机构：
[1] Wroclaw Med Univ, Dept Med Chem, Fac Pharm, Borowska 211, PL-50556 Wroclaw, Poland
来源：
PHARMACEUTICALS | 2021年 / 14卷 / 03期
关键词：
1,2,4-triazole; antimicrobial activity; antibacterial drugs; MICROWAVE IRRADIATED SYNTHESIS; BIOLOGICAL EVALUATION; ANTIMICROBIAL ACTIVITY; MOLECULAR DOCKING; IN-VITRO; MANNICH-BASES; SCHIFF-BASES; 1,2,4-TRIAZOLE-CIPROFLOXACIN HYBRIDS; POTENTIAL ANTIBACTERIAL; TRIAZOLE HYBRIDS;
D O I：
10.3390/ph14030224
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The global spread of drug resistance in bacteria requires new potent and safe antimicrobial agents. Compounds containing the 1,2,4-triazole ring in their structure are characterised by multidirectional biological activity. A large volume of research on triazole and their derivatives has been carried out, proving significant antibacterial activity of this heterocyclic core. This review is useful for further investigations on this scaffold to harness its optimum antibacterial potential. Moreover, rational design and development of the novel antibacterial agents incorporating 1,2,4-triazole can help in dealing with the escalating problems of microbial resistance.
引用
收藏
页数：28
相关论文
共 87 条
[1]   Synthesis of novel 1, 2, 4-triazolopyrimidines and their evaluation as antimicrobial agents [J].
Abu-Hashem, Ameen A. ;
Hussein, Hoda A. R. ;
Abu-zied, Khadeja M. .
MEDICINAL CHEMISTRY RESEARCH, 2017, 26 (01) :120-130
[2]   Synthesis, antimicrobial evaluation and QSAR analysis of novel nalidixic acid based 1,2,4-triazole derivatives [J].
Aggarwal, Nisha ;
Kumar, Rajesh ;
Dureja, Prem ;
Khurana, J. M. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (09) :4089-4099
[3]   Synthesis, antimicrobial, and anti-inflammatory activity, of novel S-substituted and N-substituted 5-(1-adamantyl)-1,2,4-triazole-3-thiols [J].
Al-Abdullah, Ebtehal S. ;
Asiri, Hanadi H. ;
Lahsasni, Siham ;
Habib, Elsayed E. ;
Ibrahim, Tarek M. ;
El-Emam, Ali A. .
DRUG DESIGN DEVELOPMENT AND THERAPY, 2014, 8 :505-518
[4]   Synthesis, Antimicrobial, and Anti-inflammatory Activities of Novel 5-(1-Adamantyl)-4-arylideneamino-3-mercapto-1,2,4-triazoles and Related Derivatives [J].
Al-Omar, Mohamed A. ;
Al-Abdullah, Ebtehal S. ;
Shehata, Ihsan A. ;
Habib, Elsayed E. ;
Ibrahim, Tarek M. ;
El-Emam, Ali A. .
MOLECULES, 2010, 15 (04) :2526-2550
[5]  
Al-Sdoni H.H., 2020, Eur. J. Chem, V11, P113, DOI [10.5155/eurjchem.11.2.113-119.1968, DOI 10.5155/EURJCHEM.11.2.113-119.1968]
[6]  
Ali T.E., 2010, EUR J CHEM, V1, P6, DOI [DOI 10.5155/EURJCHEM.1.1.6-11.12, 10.5155/eurjchem.1.1.6-11.12]
[7]  
[Anonymous], 2013, CHEM-US, DOI DOI 10.7598/CST2013.480
[8]  
[Anonymous], 2013, CHEM-US, DOI DOI 10.7598/CST2013.446
[9]   Synthesis, antimicrobial and antioxidant activities of imidazotriazoles and new multicomponent reaction toward 5-amino-1-phenyl[1,2,4]triazole derivatives [J].
Aouali, Monia ;
Mhalla, Dhekra ;
Allouche, Fatma ;
El Kaim, Laurent ;
Tounsi, Slim ;
Trigui, Mohamed ;
Chabchoub, Fakher .
MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (06) :2732-2741
[10]   Design and synthesis of novel 4-hydrazone functionalized/1,2,4-triazole fused pyrido[2,3-d]pyrimidine derivatives, their evaluation for antifungal activity and docking studies [J].
Appna, Nooka Ratnam ;
Nagiri, Ravi Kumar ;
Korupolu, Raghu Babu ;
Kanugala, Sirisha ;
Chityal, Ganesh Kumar ;
Thipparapu, Ganapathi ;
Banda, Narsaiah .
MEDICINAL CHEMISTRY RESEARCH, 2019, 28 (09) :1509-1528
123456789