Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents

被引：50

作者：

Camm, Kenneth D. ^{[1
]}

El-Sokkary, Ahmed ^{[1
]}

Gott, Andrew L. ^{[1
]}

Stockley, Peter G. ^{[2
]}

Belyaeva, Tamara ^{[2
]}

McGowan, Patrick C. ^{[1
]}

机构：

[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Astbury Ctr Struct Mol Biol, Leeds LS2 9JT, W Yorkshire, England

来源：

DALTON TRANSACTIONS | 2009年 / 48期

关键词：

X-RAY-STRUCTURE; ETA-6-ARENE-RUTHENIUM(II) COMPLEXES; BINDING-PROPERTIES; CRYSTAL-STRUCTURE; ARENE COMPLEXES; AMINO-ACIDS; IN-VITRO; (ETA(6)-ARENE)RUTHENIUM(II); CHEMISTRY; ANTITUMOR;

D O I：

10.1039/b918902e

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A number of new ruthenium compounds have been synthesised, isolated and characterised, which exhibit excellent cytotoxicity against a number of different human tumour cell lines including a defined cisplatin resistant cell line and colon cancer cell lines. Addition of hydrophobic groups to the ruthenium molecules has a positive effect on the cytotoxicity values. Evidence is provided that, after incubation of a ruthenium compound with a 46 mer oligonucleotide duplex and subsequent nuclease treatment, ruthenium is bound to a guanine residue.

引用

页码：10914 / 10925

页数：12

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