Defective mitosis-linked DNA damage response and chromosomal instability in liver cancer

被引：20

作者：

Tahmasebi-Birgani, Maryam ^{[1
,2
]}

Ansari, Hossein ^{[3
,4
]}

Carloni, Vinicio ^{[5
]}

机构：

[1] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Med Genet, Ahvaz, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Cellular & Mol Res Ctr, Ahvaz, Iran

[3] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Med Genet, Ahvaz, Iran

[4] Ahvaz Jundishapur Univ Med Sci, Air Pollut & Resp Dis Res Ctr, Ahvaz, Iran

[5] Univ Florence, Dept Expt & Clin Med, Largo Brambilla 3, I-50134 Florence, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2019年 / 1872卷 / 01期

关键词：

Mitotic checkpoint; DNA damage checkpoint; Defective chromosome segregations; Chromosome abnormalities; Aneuploidy; Hepatocellular carcinoma; SPINDLE ASSEMBLY CHECKPOINT; CENTROSOME AMPLIFICATION; CENP-E; OVEREXPRESSION; BREAKS; EXPRESSION; TUMORIGENESIS; SEGREGATION; PROGRESSION; ANEUPLOIDY;

D O I：

10.1016/j.bbcan.2019.05.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC), the most common form of liver cancer, represents a health problem in hepatic viruses-eradicating era because obesity, type 2 diabetes, and nonalcoholic steatohepatitis (NASH) are considered emerging pathogenic factors. Metabolic disorders underpin mitotic errors that lead to numerical and structural chromosome aberrations in a significant proportion of cell divisions. Here, we review that genomically unstable HCCs show evidence for a paradoxically DNA damage response (DDR) which leads to ongoing chromosome segregation errors. The understanding of DDR induced by defective mitoses is crucial to our ability to develop or improve liver cancer therapeutic strategies.

引用

页码：60 / 65

页数：6

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