COVID-19 vaccine: A recent update in pipeline vaccines, their design and development strategies

被引:177
作者
Rawat, Kajal [1 ]
Kumari, Puja [1 ]
Saha, Lekha [1 ]
机构
[1] Post Grad Inst Med Educ & Res PGIMER, Dept Pharmacol, 4th Floor,Res Block B, Chandigarh 160012, India
关键词
Vaccine designing; Platforms; Targets; SARS-CoV-2; COVID-19; CHINESE MEDICINE; SARS; VIRUS; CORONAVIRUS; SARS-COV-2; TRANSMISSION; INFECTIONS; RESPONSES; EFFICACY; IMMUNITY;
D O I
10.1016/j.ejphar.2020.173751
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Coronavirus Disease 2019 named as COVID-19 imposing a huge burden on public health as well as global economies, is caused by a new strain of betacoronavirus named as SARS-CoV-2. The high transmission rate of the virus has resulted in current havoc which highlights the need for a fast and effective approach either to prevent or treat the deadly infection. Development of vaccines can be the most prominent approach to prevent the virus to cause COVID-19 and hence will play a vital role in controlling the spread of the virus and reducing mortality. The virus uses its spike proteins for entering into the host by interacting with a specific receptor called angiotensin converting enzyme-2 (ACE2) present on the surface of alveolar cells in the lungs. Researchers all over the world are targeting the spike protein for the development of potential vaccines. Here, we discuss the immunopathological basis of vaccine designing that can be approached for vaccine development against SARS-CoV-2 infection and different platforms that are being used for vaccine development. We believe this review will increase our understanding of the vaccine designing against SARS-CoV-2 and subsequently contribute to the control of SARS-CoV-2 infections. Also, it gives an insight into the current status of vaccine development and associated outcomes reported at different phases of trial.
引用
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页数:12
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