Consensus statement on the use of rituximab in patients with rheumatoid arthritis

被引:168
作者
Smolen, J. S.
Keystone, E. C.
Emery, P.
Breedveld, F. C.
Betteridge, N.
Burmester, G. R.
Dougados, M.
Ferraccioli, G.
Jaeger, U.
Klareskog, L.
Kvien, T. K.
Martin-Mola, E.
Pavelka, K.
机构
[1] Med Univ Vienna, Dept Internal Med 3, Dept Rheumatol, Div Rheumatol, A-1090 Vienna, Austria
[2] Hietzing Hosp Vienna, Dept Med 2, Vienna, Austria
[3] Univ Toronto, Mt Sinai Hosp, Rebecca MacDonald Ctr Arthrit & Autoimmun, Toronto, ON M5G 1X5, Canada
[4] Chapel Allerton Hosp, Leeds Teaching Hosp Trust, Leeds, W Yorkshire, England
[5] Arthrit Care, London, England
[6] Leiden Univ, Sch Med, NL-2300 RA Leiden, Netherlands
[7] Humboldt Univ, Charite Hosp, Dept Rheumatol, D-1086 Berlin, Germany
[8] Univ Paris 05, Hop Cochin, Dept Rheumatol, F-75270 Paris 06, France
[9] Univ Cattolica Sacro Cuore, Inst Internal Med & Geriatr, Div Rheumatol, I-00168 Rome, Italy
[10] Med Univ Vienna, Dept Internal Med 1, Div Haematol, A-1090 Vienna, Austria
[11] Karolinska Hosp, Dept Rheumatol, S-10401 Stockholm, Sweden
[12] Diakonhjemmet Hosp, Dept Rheumatol, Oslo, Norway
[13] Univ Autonoma Madrid, Hosp La Paz, Dept Rheumatol, E-28049 Madrid, Spain
[14] Charles Univ Prague, Inst Rheumatol, CR-11636 Prague 1, Czech Republic
[15] Charles Univ Prague, Clin Rheumatol, CR-11636 Prague 1, Czech Republic
关键词
D O I
10.1136/ard.2006.061002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A large number of experts experienced in the treatment of rheumatoid arthritis were involved in formulating a consensus statement on the use of B cell-targeted treatment with rituximab in patients with rheumatoid arthritis. The statement was supported by data from randomised controlled clinical trials and the substantial literature on oncology. The statement underwent three rounds of discussions until its ultimate formulation. It should guide clinicians in the use of this newly approved biological agent in treating patients with rheumatoid arthritis.
引用
收藏
页码:143 / 150
页数:8
相关论文
共 42 条
[11]  
2-F
[12]   B-cell recovery following rituximab-based therapy is associated with perturbations in stromal derived factor-1 and granulocyte homeostasis [J].
Dunleavy, K ;
Hakim, F ;
Kim, HK ;
Janik, JE ;
Grant, N ;
Nakayama, T ;
White, T ;
Wright, G ;
Kwak, L ;
Gress, R ;
Tosato, G ;
Wilson, WH .
BLOOD, 2005, 106 (03) :795-802
[13]   Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis [J].
Edwards, JCW ;
Szczepanski, L ;
Szechinski, J ;
Filipowicz-Sosnowska, A ;
Emery, P ;
Close, DR ;
Stevens, RM ;
Shaw, T .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (25) :2572-2581
[14]   The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment - Results of a phase IIb randomized, double-blind, placebo-controlled, dose-ranging trial [J].
Emery, P ;
Fleischmann, R ;
Filipowicz-Sosnowska, A ;
Schechtman, J ;
Szczepanski, L ;
Kavanaugh, A ;
Racewicz, AJ ;
Van Vollenhoven, RF ;
Li, NF ;
Agarwal, S ;
Hessey, EW ;
Shaw, TM .
ARTHRITIS AND RHEUMATISM, 2006, 54 (05) :1390-1400
[15]   Treatment of rheumatoid arthritis [J].
Emery, P .
BRITISH MEDICAL JOURNAL, 2006, 332 (7534) :152-155
[16]  
EMERY P, 2006, ANN RHEUM DIS S1, V65
[17]   Updated consensus statement on biological agents, specifically tumour necrosis factor α (TNFα) blocking agents and interleukin-1 receptor antagonist (IL-1ra), for the treatment of rheumatic diseases, 2005 [J].
Furst, DE ;
Breedveld, FC ;
Kalden, JR ;
Smolen, JS ;
Burmester, GR ;
Bijlsma, JWJ ;
Dougados, M ;
Emery, P ;
Keystone, EC ;
Klareskog, L ;
Mease, PJ .
ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 :2-14
[18]  
Goekoop-Ruiterman YPM, 2005, ARTHRITIS RHEUM-US, V52, P3381, DOI 10.1002/art.23364
[19]   Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial [J].
Grigor, C ;
Capell, H ;
Stirling, A ;
McMahon, AD ;
Lock, P ;
Vallance, R ;
Kincaid, W ;
Porter, D .
LANCET, 2004, 364 (9430) :263-269
[20]   Safety of rituximab in the treatment of B cell malignancies: implications for rheumatoid arthritis [J].
Hainsworth, JD .
ARTHRITIS RESEARCH & THERAPY, 2003, 5 (Suppl 4) :S12-S16