(68Ga)-PSMA-PET/CT for the detection of postoperative prostate cancer recurrence: Possible implications on treatment volumes for radiation therapy

被引:17
作者
De Bari, B. [1 ]
Mazzola, R. [2 ,3 ]
Aiello, D. [2 ,3 ]
Aloi, D. [1 ]
Gatta, R. [2 ]
Corradini, S. [4 ]
Salgarello, M. [5 ]
Alongi, F. [2 ,3 ,6 ]
机构
[1] Ctr Hosp Reg Univ Jean Minjoz, Radiat Oncol, F-25000 Besancon, France
[2] IRCCS Sacro Cuore Don Calabria Hosp, Radiat Oncol, Negrar Verona, Italy
[3] Sacred Heart Univ Hosp, Dept Radiotherapy, Radiat oncol, Rome, Italy
[4] Ludwig Maximilians Univ Munchen, Univ Hosp, Radiat Oncol, Munich, Germany
[5] Sacro Cuore Don Calabria Hosp, Nucl Med, Negrar Verona, Italy
[6] Univ Brescia, Brescia, Italy
来源
CANCER RADIOTHERAPIE | 2019年 / 23卷 / 03期
关键词
(Ga-68)-PSMA PET/CT; Prostatic cancer; Prostatectomy; Radiotherapy; RADICAL PROSTATECTOMY; SALVAGE RADIOTHERAPY; ADJUVANT RADIOTHERAPY; ANDROGEN DEPRIVATION; PET/CT; IRRADIATION; IMMEDIATE; PATTERNS; FAILURE; RISK;
D O I
10.1016/j.canrad.2018.09.003
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose. - The aim of this study was to define the pattern of relapse of postoperative prostate cancer in patients by using 68Ga-labeled prostate -specific membrane antigen positron-emission tomography/computed tomography ([Ga-68]-PSMA PET/CT). Material and methods. - Forty patients received a (Ga-68)-PSMA PET/CT for biochemical failure. Following the Radiation Therapy Oncology Group (RTOG) guidelines, the pelvic clinical target volume has been contoured. Bone metastases were considered as outside the clinical target volume. Two subgroups of patients were defined, patients having relapse: (1) inside, or (2) outside the clinical target volume. Results. - Globally, eight patients out of 32 presented with a positive lymph node failure inside the clinical target volume according to RTOG guidelines (25%), 22 patients had nodal relapses outside this clinical target volume (68.75%) and in two patients nodal relapses occurred both inside and outside of the clinical target volume (6.25%). Overall, 36 positive lymph node lesions were identified: of these, 23 nodal relapses were identified within the clinical target volume contoured according to RTOG and/or at the lomboaortic level (63%). To cover 95% of these 23 relapses, a hypothetical clinical target volume should encompass the nodal regions of the RTOG-defined clinical target volume as well as the paraaortic lymph node level up to T12-L1. Conclusion. - Most of the patients in the present study, presented with distant lymph node and/or bone metastases. Therefore, larger target volumes should be adopted to treat at least 95% of lymph node regions at risk for an occult relapse. (C) 2019 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:194 / 200
页数:7
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