Mice Are Not Humans: The Case of p53

被引：25

作者：

Fischer, Martin ^{[1
]}

机构：

[1] Fritz Lipmann Inst FLI, Computat Biol Grp, Leibniz Inst Aging, Beutenbergstr 11, D-07745 Jena, Germany

来源：

TRENDS IN CANCER | 2021年 / 7卷 / 01期

关键词：

MOUSE MODELS; CONSERVATION; PRINCIPLES;

D O I：

10.1016/j.trecan.2020.08.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mouse models represent powerful tools in cancer research that have influenced much of our understanding of tumor development and our current anticancer strategies. Yet, central signaling pathways differ considerably between mouse and human, including gene regulatory networks (GRNs) of themost important tumor suppressor p53 and its oncogenic sibling p63.

引用

页码：12 / 14

页数：3

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