Forensic application of chiral separation of amphetamine-type stimulants to impurity analysis of seized methamphetamine by capillary electrophoresis

被引：41

作者：

Iwata, Yuko T. ^{[1
]}

Inoue, Hiroyuki ^{[1
]}

Kuwayama, Kenji ^{[1
]}

Kanamori, Tatsuyuki ^{[1
]}

Tsujikawa, Kenji ^{[1
]}

Miyaguchi, Hajime ^{[1
]}

Kishi, Tohru ^{[1
]}

机构：

[1] Natl Res Inst Police Sci, Kashiwa, Chiba 2770882, Japan

来源：

FORENSIC SCIENCE INTERNATIONAL | 2006年 / 161卷 / 2-3期

关键词：

amphetamine-type stimulants; chiral separation; impurity profiling; capillary electrophoresis; sulfated cyclodextrin; reversed polarity;

D O I：

10.1016/j.forsciint.2006.01.018

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The applicability of capillary electrophoresis (CE) with a UV detector using highly sulfated gamma-cyclodextrin as a chiral selector was examined for analysis of impurities in seized methamphetamine. Samples of methamphetamine-hydrochloride dissolved in water at a high concentration (20 mg/mL) were analyzed. Electrokinetic injection has an advantage over hydrodynamic injection for improving the detection of trace impurities. Small peaks of the precursor impurities, such as (1R,2S)-(-)-ephedrine and (1S,2S)-(+)-pseudoephedrine, were detected and quantified without extraction. The seized drugs could be classified into three groups based on the contents of the two impurities. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：92 / 96

页数：5

共 15 条

[1] Methamphetamine impurity profiling using a 0.32 mm id nonpolar capillary column [J].

Inoue, H ;

Kanamori, T ;

Iwata, YT ;

Ohmae, Y ;

Tsujikawa, K ;

Saitoh, S ;

Kishi, T .

FORENSIC SCIENCE INTERNATIONAL, 2003, 135 (01) :42-47

[2] IMPURITY PROFILING ANALYSIS OF METHAMPHETAMINE SEIZED IN JAPAN [J].

INOUE, T ;

TANAKA, K ;

OHMORI, T ;

TOGAWA, Y ;

SETA, S .

FORENSIC SCIENCE INTERNATIONAL, 1994, 69 (01) :97-102

[3]

Inoue T., 1983, REP NATL RES I POLIC, V36, P92

[4] Chiral analysis of amphetamine-type stimulants using reversed-polarity capillary electrophoresis/positive ion electrospray ionization tandem mass spectrometry [J].

Iwata, YT ;

Kanamori, T ;

Ohmae, Y ;

Tsujikawa, K ;

Inoue, H ;

Kishi, T .

ELECTROPHORESIS, 2003, 24 (11) :1770-1776

[5]

Iwata YT, 2002, ELECTROPHORESIS, V23, P1328, DOI 10.1002/1522-2683(200205)23:9<1328::AID-ELPS1328>3.0.CO

[6]

2-Z

[7] ANALYSIS OF IMPURITIES IN METHAMPHETAMINE [J].

KISHI, T ;

INOUE, T ;

SUZUKI, S ;

YASUDA, T ;

OIKAWA, T ;

NIWAGUCHI, T .

EISEI KAGAKU-JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1983, 29 (06) :400-406

[8]

Kobayashi K., 2000, NATL RES I POLICE SC, V53, P1

[9]

Nagai N., 1893, YAKUGAKU ZASSHI J PH, V139, P901

[10]

*NAT POL AG GOV JA, 2005, WHIT PAP POL 2004

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