The synthesis of new potential photosensitizers [1-3]. Part 4. Photophysical properties of some monophenyltripyridyl-porphyrin derivatives

被引：0

作者：

Kus, Piotr ^{[1
]}

Pasewicz-Sokol, Anna ^{[2
]}

Ratuszna, Alicja ^{[2
,3
]}

Rojkiewicz, Marcin ^{[1
]}

机构：

[1] Univ Silesia, Dept Chem, 9 Szkolna St, PL-40006 Katowice, Poland

[2] Univ Silesia, Chelkowski Inst Phys, PL-40007 Katowice, Poland

[3] Silesian Ctr Educ & Interdisciplinary Res, PL-41500 Chorzow, Poland

来源：

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES | 2015年 / 19卷 / 11期

关键词：

photosensitizers; porphyrins; fluorescence; UV-vis; singlet oxygen; tetrapyrroles; ENANTIOSELECTIVE RECOGNITION; DNA; TETRAPHENYLPORPHYRIN; CONJUGATE; DESIGN; AGENTS;

D O I：

10.1142/S1088424615501047

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Six monophenyltripyridylporphyrin derivatives were synthesized and characterized by spectroscopy in order to demonstrate their potential usefulness as photosensitizers for anticancer therapy purposes. Compounds 1 and 3-5 are amphiphilic, thus they may be suitable for transfer inside cells. Photochemical parameters such as fluorescence yield and singlet oxygen yield were determined. The former parameter does not exceed 10% which makes them unsuitable for photodynamic diagnosis (PDD). However, singlet oxygen yields are high and sufficient for these compounds to be considered as potential photodynamic therapy (PDT) photosensitizers.

引用

页码：1204 / 1211

页数：8

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