Dieckol, an algae-derived phenolic compound, suppresses airborne particulate matter-induced skin aging by inhibiting the expressions of pro-inflammatory cytokines and matrix metalloproteinases through regulating NF-κB, AP-1, and MAPKs signaling pathways

被引：28

作者：

Wang, Lei ^{[1
,2
]}

Lee, WonWoo ^{[3
]}

Jayawardena, Thilina U. ^{[1
]}

Cha, Seon-Heui ^{[4
]}

Jeon, You-Jin ^{[1
,2
]}

机构：

[1] Jeju Natl Univ, Dept Marine Life Sci, Jeju 63243, South Korea

[2] Jeju Natl Univ, Marine Sci Inst, Jeju Self Governing Prov, Jeju City 63333, Jeju Self Gover, South Korea

[3] Nakdonggang Natl Inst Biol Resources, Freshwater Bioresources Utilizat Div, Sangju 37242, South Korea

[4] Hanseo Univ, Dept Marine Bio & Med Sci, Chungcheognam Do 32158, South Korea

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2020年 / 146卷

关键词：

Chinese particulate matter; Matrix metalloproteinases; Pro-inflammatory cytokines; Human dermal fibroblasts; Zebrafish; CELLS; EXTRACT;

D O I：

10.1016/j.fct.2020.111823

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Exposure to particulate matter causes skin aging. In the present study, we investigated the effect of an algae-derived phenolic compound, dieckol (DK), against Chinese particulate matter (CPM)-stimulated aging in vitro in human dermal fibroblasts (HDF cells) and in vivo in zebrafish. DK effectively protected HDF cells against CPM-induced oxidative stress by scavenging intracellular reactive oxygen species. Moreover, DK significantly improved collagen synthesis and inhibited intracellular collagenase activity in CPM-stimulated HDF cells. In addition, DK remarkably reduced the expression of pro-inflammatory cytokines and matrix metallopmteinases via regulating the nuclear factor kappa B, activator protein 1, and mitogen-activated protein kinases signaling pathways in CPM-stimulated HDF cells. Furthermore, the in vivo test results demonstrated that DK effectively improved the survival rate of CPM-stimulated zebrafish via suppressing oxidative stress and inflammatory response. In conclusion, this study suggests that DK is a potential anti-aging compound that can be used as a therapeutic agent to improve CPM-induced skin aging, or as an ingredient to develop a cosmetic or medicine in the cosmeceutical and pharmaceutical industries.

引用

页数：10

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