Evidence for type-specific DNA methylation patterns in epilepsy: a discordant monozygotic twin approach

被引：15

作者：

Mohandas, Namitha ^{[1
,2
]}

Loke, Yuk Jing ^{[1
]}

Hopkins, Stephanie ^{[1
,7
]}

Mackenzie, Lisa ^{[3
]}

Bennett, Carmen ^{[3
]}

Berkovic, Samuel F. ^{[5
]}

Vadlamudi, Lata ^{[3
,4
]}

Craig, Jeffrey M. ^{[1
,2
,6
]}

机构：

[1] Royal Childrens Hosp, Environm & Genet Epidemiol Res, Murdoch Childrens Res Inst, Flemington Rd, Parkville, Vic, Australia

[2] Univ Melbourne, Dept Paediat, Flemington Rd, Parkville, Vic, Australia

[3] Univ Queensland, Ctr Clin Res, Fac Med, Brisbane, Qld, Australia

[4] Royal Brisbane & Womens Hosp, Herston, Qld, Australia

[5] Univ Melbourne, Austin Hlth, Epilepsy Res Ctr, Melbourne, Vic, Australia

[6] Deakin Univ, Ctr Mol & Med Res, Sch Med, Geelong, Vic 3220, Australia

[7] Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW, Australia

来源：

EPIGENOMICS | 2019年 / 11卷 / 08期

关键词：

discordant monozygotic twins; DNA methylation; epigenetics; epilepsy; PROMOTER METHYLATION; MICE LACKING; BRAIN; BLOOD; GENETICS; WIDE; INTERNEURONS; BIOMARKERS; INTEGRINS; SCLEROSIS;

D O I：

10.2217/epi-2018-0136

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: Epilepsy is a common neurological disorder characterized by recurrent seizures. We performed epigenetic analyses between and within 15 monozygotic (MZ) twin pairs discordant for focal or generalized epilepsy. Methods: DNA methylation analysis was performed using Illumina Infinium MethylationEPIC arrays, in blood and buccal samples. Results: Differentially methylated regions between epilepsy types associated with PM20D1 and GFPT2 genes in both tissues. Within MZ discordant twin pairs, differentially methylated regions associated with OTX1 and ARID5B genes for generalized epilepsy and TTC39C and DUG genes for focal epilepsy. Conclusion: This is the first epigenome-wide association study, utilizing the discordant MZ co-twin model, to deepen our understanding of the neurobiology of epilepsy.

引用

页码：951 / 968

页数：18

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