Cancer Genome Sequencing-An Interim Analysis

被引：50

作者：

Fox, Edward J. ^{[1
]}

Salk, Jesse J. ^{[1
]}

Loeb, Lawrence A. ^{[1
]}

机构：

[1] Univ Washington, Dept Pathol, Joseph Gottstein Mem Lab, Seattle, WA 98195 USA

来源：

CANCER RESEARCH | 2009年 / 69卷 / 12期

关键词：

ACUTE MYELOID-LEUKEMIA; COLORECTAL CANCERS; MUTATIONAL ANALYSIS; SOMATIC MUTATIONS; TYROSINE KINOME; HUMAN BREAST; PATHWAYS; GENES; CELLS;

D O I：

10.1158/0008-5472.CAN-09-1231

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With the publishing of the first complete whole genome of a human cancer and its paired normal, we have passed a key milestone in the cancer genome sequencing strategy. The generation of such data will, thanks to technical advances, soon become commonplace. As a significant number of proof-of-concept studies have been published, it is important to analyze now the likely implications of these data and how this information might frame cancer research in the near future. The diversity of genes mutated within individual tumor types, the most striking feature of all studies reported to date, challenges gene-centric models of tumorigenesis. Although cancer genome sequencing will revolutionize certain aspects of personalized care, the value of these studies in facilitating the development of new therapies, their primary goal, seems less promising. Most significantly, however, the cancer genome sequencing strategy, as currently applied, fails to characterize the most relevant genomic features of cancer-the mutational heterogeneity within individual tumors. [Cancer Res 2009;69(12):4948-50]

引用

页码：4948 / 4950

页数：3

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