Euplectin and coneuplectin, new naphthopyrones from the lichen Flavoparmelia euplecta

被引：89

作者：

Ernst-Russell, MA ^{[1
]}

Chai, CLL ^{[1
]}

Wardlaw, JH ^{[1
]}

Elix, JA ^{[1
]}

机构：

[1] Australian Natl Univ, The Fac, Dept Chem, Canberra, ACT 0200, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 01期

关键词：

D O I：

10.1021/np9903245

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new naphthopyrones, euplectin (1) and coneuplectin (2), have been isolated from the lichen Flavoparmelia euplecta and their structures elucidated using multidimensional NMR spectroscopic methods, including highfield (600 MHz) gHMBC and gNOE experiments. Cytotoxicity of the more abundant naphthopyrone (1) against the murine P-815 mastocytoma cell line (IC50 ca. 1.67 mu g/mL) has also been evaluated. These compounds are the first lichen metabolites known to contain indenone or indanone moieties in their structure. F. euplecta was also;found to contain the known metabolites usnic acid, protocetraric acid, and skyrin.

引用

页码：129 / 131

页数：3

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