Connective tissue growth factor - Friend or foe?

被引：137

作者：

Oemar, BS ^{[1
]}

Luscher, TF ^{[1
]}

机构：

[1] UNIV ZURICH HOSP, CH-8091 ZURICH, SWITZERLAND

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 1997年 / 17卷 / 08期

关键词：

atherosclerosis; development; fibrosis; gene expression; gene cloning;

D O I：

10.1161/01.ATV.17.8.1483

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Connective tissue growth factor (CTGF) is a novel cysteine-rich, secreted peptide, which is implicated in human atherosclerosis and fibrotic disorders such as systemic scleroderma. CTGF is a member of the peptide family that includes serum-induced immediate early gene products, a v-src-induced peptide, and a putative proto-oncogene. The CTGF gene family is a modular protein and is conserved throughout evolution. CTGF mRNA has been found in the human, mouse, chicken, frog, and fly. The functions of the CTGF gene family include embryogenesis, wound healing, and regulation of extracellular matrix production. Human CTGF is undetectable in normal blood vessels but overexpressed in atherosclerotic lesions, suggesting an important role in atherogenesis.

引用

页码：1483 / 1489

页数：7

共 40 条

[1] CLONING AND CHARACTERIZATION OF THE GROWTH HORMONE-DEPENDENT INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN (IGFBP-3) IN THE RAT [J].