Dietary supplementation with long chain polyunsaturated fatty acids in pregnant guinea pigs has sex-dependent effects on growth and bone outcomes in offspring

被引：4
作者：
Yin, Z. [1 ]
Agellon, S. [1 ]
Lavery, P. [1 ]
Weiler, H. [1 ]
机构：
[1] McGill Univ, Sch Dietet & Human Nutr, Quebec City, PQ H9X 3V9, Canada
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2014年 / 91卷 / 1-2期
关键词：
Long chain PUFA; Maternal; Offspring; Bone mass; Guinea pig; FISH-OIL SUPPLEMENTATION; VITAMIN-D DEFICIENCY; DOCOSAHEXAENOIC ACID; HUMAN-MILK; MATERNAL SUPPLEMENTATION; ARACHIDONIC-ACID; MINERAL DENSITY; MASS; N-3; LACTATION;
D O I：
10.1016/j.plefa.2014.05.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long chain PUFA enhance bone mass in non-pregnant mammals. We examined the effects of arachidonic (AA; 20:4n-6) and docosahexaenoic (DHA; 22:6n-3) acid on bone mass of mothers and neonates. Guinea pig sows (n=15) were fed control, DHA or AA+DHA diets from mating to weaning. Measurements included: osteocalcin (OC), deoxypyridinoline (DPD), areal bone mineral density (aBMD) in sows and neonates; and volumetric density (vBMD) in neonates. Only vertebral aBMD and OC:DPD ratio declined during reproduction and only DHA reduced OC:DPD. Male pup weight was reduced by DHA and female weight elevated by AA+DHA. Whole body and femur aBMD were reduced by DHA and AA+DHA; whereas tibia vBMD was reduced by DHA in males. Female whole body, tibia and vertebrae aBMD plus tibia vBMD were elevated by AA+DHA; and DHA elevated whole body, tibia and vertebrae aBMD. Dietary AA+DHA and DHA elicit sex-dependent effects on neonatal bone, with minimal impact on mothers. (C) 2014 Elsevier Ltd. All rights reserved.
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页码：31 / 38
页数：8
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