Paths to the pancreas

被引：9

作者：

Bort, R ^{[1
]}

Zaret, K ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Program Cell & Dev Biol, Philadelphia, PA 19111 USA

来源：

NATURE GENETICS | 2002年 / 32卷 / 01期

关键词：

D O I：

10.1038/ng0902-85

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Understanding how transcription factors control early pancreas development can yield insight into digestive diseases and guide protocols for therapeutic stem-cell differentiation. A new study, using a sensitive lineage-marking approach, shows that the transcription factor Ptf1a is critical to the specification of pancreatic endocrine, exocrine and duct cells in mice. This indicates an earlier and more pervasive influence of Ptf1a on organogenesis than was previously revealed by standard gene inactivation.

引用

页码：85 / 86

页数：2

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