Recent developments in atopic dermatitis

被引：22

作者：

Peng, Wenming ^{[1
]}

Novak, Natalija ^{[1
]}

机构：

[1] Univ Bonn, Dept Dermatol & Allergy, D-53105 Bonn, Germany

来源：

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY | 2014年 / 14卷 / 05期

关键词：

atopic dermatitis; epigenetics; innate lymphoid cells; microbiome; INNATE LYMPHOID-CELLS; REGULATORY T-CELLS; DENDRITIC CELLS; SUSCEPTIBILITY LOCI; SKIN MICROBIOME; DEFICIENT MICE; EXPRESSION; INFLAMMATION; CYTOKINES; POLYMORPHISMS;

D O I：

10.1097/ACI.0000000000000094

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Purpose of review Research on atopic dermatitis is actively growing and continuously completing our knowledge on the pathophysiology of this complex disease. Recent findings Genome-wide association studies revealed new susceptibility loci for atopic dermatitis. In addition, different tissue-specific patterns of DNA methylation have been identified as first evidence for the relevance of epigenetic modifications in atopic dermatitis. Moreover, interest is emerging on the role of the skin and gut microbiome in atopic dermatitis. Signals mediated via pattern recognition receptors of the innate immune system have been analyzed in more detail, and the role of cytokines, such as IL-22, IL-25, IL-31 and IL-33 as well as innate lymphoid cells, has been studied. Summary Taken together, better knowledge of atopic dermatitis pathways will form the basis for the development of rationale-based therapeutic approaches in the future.

引用

页码：417 / 422

页数：6