A novel class of small RNAs in mouse spermatogenic cells

被引：678

作者：

Grivna, Shane T.

Beyret, Ergin

Wang, Zhong

Lin, Haifan ^{[1
]}

机构：

[1] Duke Univ, Dept Cell Biol, Durham, NC 27710 USA

[2] Duke Univ, Dept Pharmacol & Mol Canc Biol, Durham, NC 27710 USA

[3] Duke Univ, Inst Genome Sci & Policy, Durham, NC 27710 USA

来源：

GENES & DEVELOPMENT | 2006年 / 20卷 / 13期

关键词：

piRNA; gsRNA; spermatogenesis; sperniatid; mouse; MIWI;

D O I：

10.1101/gad.1434406

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Small noncoding RNAs, including small interfering RNAs (siRNAs) and micro RNAs (miRNAs) of similar to 21 nucleotides (nt) in length, have emerged as potent regulators of gene expression at both transcriptional and post-transcriptional levels in diverse organisms. Here we report the identification of a novel class of small RNAs in the mouse male germline termed piwi-interacting RNAs (piRNAs). piRNAs are similar to 30 nt in length. They are expressed during spermatogenesis, mostly in spermatids. piRNAs are associated with MIWI, a spermatogenesis-specific PIWI subfamily member of the Argonaute protein family, and depend on MIWI for their biogenesis and/or stability. Furthermore, a subpopulation of piRNAs are associated with polysomes, suggesting their potential role in translational regulation.

引用

页码：1709 / 1714

页数：6

共 25 条

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