Aspects of Degradation Kinetics of Azithromycin in Aqueous Solution

被引:22
作者
Zhang, Yu [1 ]
Liu, Xiaoliang [2 ]
Cui, Yue [1 ]
Huang, Huifeng [1 ]
Chi, Na [1 ]
Tang, Xing [1 ]
机构
[1] Shenyang Pharmaceut Univ, Dept Pharm, Shenyang 110016, Peoples R China
[2] Liaoning Med Ind Co Ltd, Shenyang 110005, Peoples R China
关键词
Column liquid chromatography; Azithromycin and desosaminylazithromycin; Stability and degradation; MASS-SPECTROMETRY; PLASMA; ERYTHROMYCIN; DERIVATIVES; TISSUES;
D O I
10.1365/s10337-009-1116-x
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The chemical stability of azithromycin (AZM) in aqueous solution has been investigated utilizing a stability-indicating LC assay with ultraviolet detection. The degradation kinetics were studied as functions of pH (4-7.2), buffer composition (phosphate, acetate, and citrate), buffer concentration, ionic strength, drug concentration and temperature. The observed rate obtained by measuring the remaining intact AZM was shown to follow pseudo-first-order kinetics. The maximum stability of AZM occured at an approximate pH 6.3 in 0.05 M potassium phosphate. The observed degradation rate increased with ionic strength, buffer concentration and obeyed the Arrhenius equation over the temperature range investigated (70-100 A degrees C). The apparent energy of activation (E (a)) for AZM in solution was found to be 96.8 kJ mol(-1) and by application of the Arrhenius equation the stability at 25 A degrees C (k (25)) and 40 A degrees C (k (40)) had been predicted. Moreover, the degradation rate of AZM was independent on its initial concentration. Trace metal ions are unlikely to be involved in the degradation of AZM in aqueous solution. The major degradation product of AZM in aqueous solution was isolated and identified by LC-MS-MS and H-1 and C-13 NMR spectra.
引用
收藏
页码:67 / 73
页数:7
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