Dietary Carotenoid Roles in Redox Homeostasis and Human Health

被引：49

作者：

Barros, Marcelo P. ^{[1
,2
]}

Rodrigo, Maria J. ^{[2
]}

Zacarias, Lorenzo ^{[2
]}

机构：

[1] Cruzeiro do Sul Univ, Inst Phys Act & Sports Sci ICAFE, Rua Galvao Bueno 868,Bldg B,13th Floor, BR-01506000 Sao Paulo, SP, Brazil

[2] CSIC, IATA, Dept Biotecnol Alimentos, Calle Catedrat Agustin Escardino 7, Paterna 46980, Spain

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2018年 / 66卷 / 23期

关键词：

oxidative stress; antioxidant; Nif2; free radicals; apocarotenoid; inflammation; apoptosis; redox switch; OXIDATIVE STRESS; CELL-DEATH; ASTAXANTHIN; DERIVATIVES; METABOLISM; NUTRITION; APOPTOSIS; LYCOPENE;

D O I：

10.1021/acs.jafc.8b00866

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Classic nutrition believed that healthy diets should simply provide sufficient antioxidant loads to organisms, to hamper free radical processes and avoid oxidative stress. Current redox biology was proven much more intricate. Carotenoids are bioactive compounds in the human diet with a multifaceted role in redox metabolism. This perspective discusses the participation of alpha/beta-carotene, lutein, zeaxanthin, lycopene, beta-cryptoxanthin, astaxanthin, and derivatives in redox homeostasis focusing on (i) their antioxidant/pro-oxidant activities, (ii) control of gene expression via Nrf2-Keapl and NF-kappa B pathways, and (iii) their link with (sub)cellular redox circuits, as part of the "redox code" that orchestrates physiological processes and health in humans.

引用

页码：5733 / 5740

页数：8

共 35 条

[1]

Agricultural Research Service (ARS) United States Department of Agriculture (USDA), 2012, WHAT WE EAT AM NAT H

[2] Certain carotenoids enhance the intracellular glutathione level in a murine cultured macrophage cell line by inducing glutamate-cysteine-ligase [J].

Akaboshi, Teppei ;

Yamanishi, Rintaro .

MOLECULAR NUTRITION & FOOD RESEARCH, 2014, 58 (06) :1291-1300

[3] Combined astaxanthin and fish oil supplementation improves glutathione-based redox balance in rat plasma and neutrophils [J].

Barros, Marcelo Paes ;

Marin, Douglas Popp ;

Bolin, Anaysa Paola ;

Santos Macedo, Rita de Cassia ;

Campoio, Thais Regina ;

Fineto, Claudio, Jr. ;

Guerra, Beatriz Alves ;

Polotow, Tatiana Geraldo ;

Vardaris, Cristina ;

Mattei, Rita ;

Otton, Rosemari .

CHEMICO-BIOLOGICAL INTERACTIONS, 2012, 197 (01) :58-67

[4] Assessment of dietary vitamin A intake (retinol, α-carotene, β-carotene, β-cryptoxanthin) and its sources in the National Survey of Dietary Intake in Spain (2009-2010) [J].

Beltran-de-Miguel, Beatriz ;

Estevez-Santiago, Rocio ;

Olmedilla-Alonso, Begona .

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2015, 66 (06) :706-712

[5] Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans [J].

Bohn, Torsten ;

Desmarchelier, Charles ;

Dragsted, Lars O. ;

Nielsen, Charlotte S. ;

Stahl, Wilhelm ;

Ruhl, Ralph ;

Keijer, Jaap ;

Borel, Patrick .

MOLECULAR NUTRITION & FOOD RESEARCH, 2017, 61 (06)

[6] Gene signature of breast cancer cell lines treated with lycopene [J].

Chalabi, Nassera ;

Delort, Laetitia ;

Le Corre, Ludovic ;

Satih, Samir ;

Bignon, Yves-Jean ;

Bernard-Gallon, Dominique .

PHARMACOGENOMICS, 2006, 7 (05) :663-672

[7] Gene-Dairy Food Interactions and Health Outcomes: A Review of Nutrigenetic Studies [J].

Comerford, Kevin B. ;

Pasin, Gonca .

NUTRIENTS, 2017, 9 (07)

[8] Main food sources of carotenoids, according to the purpose and degree of processing, for beneficiaries of the 'Bolsa Familia' in Brazil [J].

de Oliveira Sartori, Alan Giovanini ;

da Silva, Marina Vieira .

FOOD SCIENCE AND TECHNOLOGY, 2014, 34 (02) :408-415

[9] Overview of carotenoid bioavailability determinants: From dietary factors to host genetic variations [J].

Desmarchelier, Charles ;

Borel, Patrick .

TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2017, 69 :270-280

[10] Apoptosis: A review of programmed cell death [J].

Elmore, Susan .

TOXICOLOGIC PATHOLOGY, 2007, 35 (04) :495-516

← 1 2 3 4 →