Diabetes Mellitus and Liver Cancer Risk: An Evaluation Based on a Systematic Review of Epidemiologic Evidence among the Japanese Population

被引：29

作者：

Tanaka, Keitaro ^{[1
]}

Tsuji, Ichiro ^{[2
]}

Tamakoshi, Akiko ^{[3
]}

Matsuo, Keitaro ^{[4
]}

Wakai, Kenji ^{[5
]}

Nagata, Chisato ^{[6
]}

Mizoue, Tetsuya ^{[7
]}

Inoue, Manami ^{[8
,9
]}

Tsugane, Shoichiro ^{[9
]}

Sasazuki, Shizuka ^{[9
]}

机构：

[1] Saga Univ, Dept Prevent Med, Fac Med, Saga 8498501, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Publ Hlth & Forens Med, Div Epidemiol, Sendai, Miyagi 980, Japan

[3] Hokkaido Univ, Grad Sch Med, Dept Publ Hlth, Sapporo, Hokkaido, Japan

[4] Kyushu Univ, Grad Sch Med Sci, Dept Prevent Med, Fukuoka 812, Japan

[5] Nagoya Univ, Dept Prevent Med, Grad Sch Med, Nagoya, Aichi 4648601, Japan

[6] Gifu Univ, Dept Epidemiol & Prevent Med, Grad Sch Med, Gifu, Japan

[7] Natl Ctr Global Hlth & Med, Int Clin Res Ctr, Dept Epidemiol & Prevent, Tokyo, Japan

[8] Univ Tokyo, Grad Sch Med, AXA Dept Hlth & Human Soc, Tokyo, Japan

[9] Natl Canc Ctr, Epidemiol & Prevent Div, Res Ctr Canc Prevent & Screening, Tokyo 104, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2014年 / 44卷 / 10期

关键词：

liver cancer; diabetes; systematic review; epidemiology; Japanese; CHRONIC HEPATITIS-C; B-VIRUS INFECTION; LOW-IRON DIET; HEPATOCELLULAR-CARCINOMA; FOLLOW-UP; ALCOHOLIC CIRRHOSIS; GLUCOSE-TOLERANCE; CIGARETTE-SMOKING; OBESITY; METAANALYSIS;

D O I：

10.1093/jjco/hyu108

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: The potential associations of diabetes mellitus with malignant neoplasms including liver cancer have become a great concern from both clinical and preventive perspectives. Although sufficient evidence for a positive association between diabetes and liver cancer already exists, it would be informative to summarize up-to-date epidemiologic data in Japan. Methods: We systematically reviewed epidemiologic studies on diabetes and liver cancer among Japanese populations. Original data were obtained by searching the MEDLINE (PubMed) and Ichushi databases, complemented with manual searches. The evaluation was performed in terms of the magnitude of association in each study and the strength of evidence ('convincing', 'probable', 'possible' or 'insufficient'), together with biological plausibility. Results: We identified 19 cohort studies, one pooled-analysis of seven cohort studies, and seven case-control studies. Of 24 relative risk estimates of liver cancer for diabetes reported in those cohort studies, 17 showed a weak to strong positive association, six revealed no association and one demonstrated a weak inverse association (summary relative risk 2.10, 95% confidence interval 1.60-2.76). Ten relative risk estimates from the case-control studies showed a weak to strong positive association (n = 9) or no association (n = 1; summary relative risk 2.32, confidence interval 1.73-3.12). Overall, the summary relative risk became 2.18 (confidence interval 1.78-2.69). Heterogeneity in relative risks was significant for the difference in categories of study population (P = 0.01), but not in study type (P = 0.39) or sex (P = 0.33). Conclusions: Diabetes mellitus 'probably' increases the risk of liver cancer among the Japanese population.

引用

页码：986 / 999

页数：14