IL-17 and "TH2-high" asthma: Adding fuel to the fire?

被引：14

作者：

Bhakta, Nirav R. ^{[1
]}

Erle, David J. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2014年 / 134卷 / 05期

关键词：

Asthma: cellular/molecular mechanisms; cytokines; endotype; IL-13; IL-17; INNATE LYMPHOID-CELLS; AIRWAY HYPERRESPONSIVENESS; T-CELLS; INFLAMMATION; PRODUCE; SUBSET;

D O I：

10.1016/j.jaci.2014.07.034

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：1187 / 1188

页数：2

共 15 条

[1] IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia [J].

Aujla, Shean J. ;

Chan, Yvonne R. ;

Zheng, Mingquan ;

Fei, Mingjian ;

Askew, David J. ;

Pociask, Derek A. ;

Reinhart, Todd A. ;

McAllister, Florencia ;

Edeal, Jennifer ;

Gaus, Kristi ;

Husain, Shahid ;

Kreindler, James L. ;

Dubin, Patricia J. ;

Pilewski, Joseph M. ;

Myerburg, Mike M. ;

Mason, Carol A. ;

Iwakura, Yoichiro ;

Kolls, Jay K. .

NATURE MEDICINE, 2008, 14 (03) :275-281

[2] IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? [J].

Bullens, Dominique M. A. ;

Truyen, Els ;

Coteur, Liesbeth ;

Dilissen, Ellen ;

Hellings, Peter W. ;

Dupont, Lieven J. ;

Ceuppens, Jan L. .

RESPIRATORY RESEARCH, 2006, 7 (1)

[3] Randomized, Double-Blind, Placebo-controlled Study of Brodalumab, a Human Anti-IL-17 Receptor Monoclonal Antibody, in Moderate to Severe Asthma [J].

Busse, William W. ;

Holgate, Stephen ;

Kerwin, Edward ;

Chon, Yun ;

Feng, JingYuan ;

Lin, Joseph ;

Lin, Shao-Lee .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 188 (11) :1294-1302

[4] Lebrikizumab Treatment in Adults with Asthma [J].

Corren, Jonathan ;

Lemanske, Robert F., Jr. ;

Hanania, Nicola A. ;

Korenblat, Phillip E. ;

Parsey, Merdad V. ;

Arron, Joseph R. ;

Harris, Jeffrey M. ;

Scheerens, Heleen ;

Wu, Lawren C. ;

Su, Zheng ;

Mosesova, Sofia ;

Eisner, Mark D. ;

Bohen, Sean P. ;

Matthews, John G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (12) :1088-1098

[5] Identification of a novel subset of human circulating memory CD4+ T cells that produce both IL-17A and IL-4 [J].

Cosmi, Lorenzo ;

Maggi, Laura ;

Santarlasci, Veronica ;

Capone, Manuela ;

Cardilicchia, Elisa ;

Frosali, Francesca ;

Querci, Valentina ;

Angeli, Roberta ;

Matucci, Andrea ;

Fambrini, Massimiliano ;

Liotta, Francesco ;

Parronchi, Paola ;

Maggi, Enrico ;

Romagnani, Sergio ;

Annunziato, Francesco .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (01) :222-230

[6] Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD [J].

Doe, Camille ;

Bafadhel, Mona ;

Siddiqui, Salman ;

Desai, Dhananjay ;

Mistry, Vijay ;

Rugman, Paul ;

McCormick, Margaret ;

Woods, Joanne ;

May, Richard ;

Sleeman, Matthew A. ;

Anderson, Ian K. ;

Brightling, Christopher E. .

CHEST, 2010, 138 (05) :1140-1147

[7] Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma [J].

Irvin, Chaoyu ;

Zafar, Iram ;

Good, James ;

Rollins, Donald ;

Christianson, Christina ;

Gorska, Magdalena M. ;

Martin, Richard J. ;

Alam, Rafeul .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 134 (05) :1175-+

[8] Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity [J].

Kim, Hye Young ;

Lee, Hyun Jun ;

Chang, Ya-Jen ;

Pichavant, Muriel ;

Shore, Stephanie A. ;

Fitzgerald, Katherine A. ;

Iwakura, Yoichiro ;

Israel, Elliot ;

Bolger, Kenneth ;

Faul, John ;

DeKruyff, Rosemarie H. ;

Umetsu, Dale T. .

NATURE MEDICINE, 2014, 20 (01) :54-+

[9] IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction [J].

Kudo, Makoto ;

Melton, Andrew C. ;

Chen, Chun ;

Engler, Mary B. ;

Huang, Katherine E. ;

Ren, Xin ;

Wang, Yanli ;

Bernstein, Xin ;

Li, John T. ;

Atabai, Kamran ;

Huang, Xiaozhu ;

Sheppard, Dean .

NATURE MEDICINE, 2012, 18 (04) :547-554

[10] TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice [J].

McKinley, Laura ;

Alcorn, John F. ;

Peterson, Alanna ;

DuPont, Rachel B. ;

Kapadia, Shernaaz ;

Logar, Alison ;

Henry, Adam ;

Irvin, Charles G. ;

Piganelli, Jon D. ;

Ray, Anuradha ;

Kolls, Jay K. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (06) :4089-4097

← 1 2 →