Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury

被引：11
作者：
Dong, Yuzhen [1 ]
Yang, Libin [1 ]
Yang, Lin [1 ]
Zhao, Hongxing [1 ]
Zhang, Chao [1 ]
Wu, Dapeng [1 ]
机构：
[1] Xinxiang Med Coll, Dept Orthoped, Affiliated Hosp 1, Weihui, Henan Province, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 16期
关键词：
nerve regeneration; spinal cord injury; cell transplantation; neurotrophin-3; bone marrow mesenchymal stem cells; cell apoptosis; spinal cord anterior horn motor neurons; neural regeneration; AXONAL REGENERATION; FUNCTIONAL RECOVERY; NEUROTROPHIC FACTOR; RATS; THERAPY; DIFFERENTIATION;
D O I：
10.4103/1673-5374.139478
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. However, the low survival rate of transplanted bone marrow mesenchymal stem cells in vivo remains a problem. Neurotrophin-3 promotes motor neuron survival and it is hypothesized that its transfection can enhance the therapeutic effect. We show that in vitro transfection of neurotrophin-3 gene increases the number of bone marrow mesenchymal stem cells in the region of spinal cord injury. These results indicate that neurotrophin-3 can promote the survival of bone marrow mesenchymal stem cells transplanted into the region of spinal cord injury and potentially enhance the therapeutic effect in the repair of spinal cord injury.
引用
收藏
页码：1520 / 1524
页数：5
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