Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury

被引：11
|
作者：
Dong, Yuzhen [1 ]
Yang, Libin [1 ]
Yang, Lin [1 ]
Zhao, Hongxing [1 ]
Zhang, Chao [1 ]
Wu, Dapeng [1 ]
机构：
[1] Xinxiang Med Coll, Dept Orthoped, Affiliated Hosp 1, Weihui, Henan Province, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 16期
关键词：
nerve regeneration; spinal cord injury; cell transplantation; neurotrophin-3; bone marrow mesenchymal stem cells; cell apoptosis; spinal cord anterior horn motor neurons; neural regeneration; AXONAL REGENERATION; FUNCTIONAL RECOVERY; NEUROTROPHIC FACTOR; RATS; THERAPY; DIFFERENTIATION;
D O I：
10.4103/1673-5374.139478
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. However, the low survival rate of transplanted bone marrow mesenchymal stem cells in vivo remains a problem. Neurotrophin-3 promotes motor neuron survival and it is hypothesized that its transfection can enhance the therapeutic effect. We show that in vitro transfection of neurotrophin-3 gene increases the number of bone marrow mesenchymal stem cells in the region of spinal cord injury. These results indicate that neurotrophin-3 can promote the survival of bone marrow mesenchymal stem cells transplanted into the region of spinal cord injury and potentially enhance the therapeutic effect in the repair of spinal cord injury.
引用
收藏
页码：1520 / 1524
页数：5
相关论文
共 50 条
  • [11] Bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury
    Liu, Yu
    Zhang, Boai
    Song, Yi
    Deng, Yubin
    Jia, Yanjie
    Gong, Qiyong
    NEURAL REGENERATION RESEARCH, 2011, 6 (13) : 978 - 982
  • [12] Transplantation of neurotrophin-3-expressing bone mesenchymal stem cells improves recovery in a rat model of spinal cord injury
    Wang, Ling-Jie
    Zhang, Rui-Ping
    Li, Jian-Ding
    ACTA NEUROCHIRURGICA, 2014, 156 (07) : 1409 - 1418
  • [13] Transplantation of neurotrophin-3-expressing bone mesenchymal stem cells improves recovery in a rat model of spinal cord injury
    Ling-Jie Wang
    Rui-Ping Zhang
    Jian-Ding Li
    Acta Neurochirurgica, 2014, 156 : 1409 - 1418
  • [14] Transplantation of bone marrow mesenchymal stem cells alleviates spinal cord injury via inhibiting Notch signaling
    Chen, Y.
    Lian, X-H.
    Liao, L-Y.
    Liu, Y-T.
    Liu, S-L.
    Gao, Q.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 : 31 - 38
  • [15] Cell transplantation therapies for spinal cord injury focusing on bone marrow mesenchymal stem cells: Advances and challenges
    Huang, Li-Yi
    Sun, Xin
    Pan, Hong-Xia
    Wang, Lu
    He, Cheng-Qi
    Wei, Quan
    WORLD JOURNAL OF STEM CELLS, 2023, 15 (05): : 385 - 399
  • [16] Study on Application of Bone Marrow Mesenchymal Stem Cells Transplantation in Restorative Treatment of Spinal Cord Injury in Mice
    Sun, Yang
    Jiang, Zhongjing
    Tang, Hao
    Xie, Jiang
    JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2020, 10 (08) : 1122 - 1127
  • [17] Effect of the transplantation of hypoxia-preconditioned bone marrow mesenchymal stem cells on spinal cord injury in rat
    Xu, Haibo
    Xu, Xinliang
    Zhou, Haiguang
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2021, 128 : 60 - 61
  • [18] Transplantation of autologous bone marrow mesenchymal stem cells in the treatment of complete and chronic cervical spinal cord injury
    Dai, Guanghui
    Liu, Xuebin
    Zhang, Zan
    Yang, Zhijun
    Dai, Yiwu
    Xu, Ruxiang
    BRAIN RESEARCH, 2013, 1533 : 73 - 79
  • [19] Effect of intravenous transplantation of bone marrow mesenchymal stem cells on neurotransmitters and synapsins in rats with spinal cord injury
    Chen, Shaoqiang
    Wu, Bilian
    Lin, Jianhua
    NEURAL REGENERATION RESEARCH, 2012, 7 (19) : 1445 - 1453
  • [20] Effect of intravenous transplantation of bone marrow mesenchymal stem cells on neurotransmitters and synapsins in rats with spinal cord injury
    Shaoqiang Chen1
    Neural Regeneration Research, 2012, 7 (19) : 1445 - 1453
12345