COMPARTMENTALIZATION IN CEPHALOSPORIN C BIOSYNTHESIS BY INDUSTRIAL STRAINS OF ACREMONIUM CHRYSOGENUM

被引：0

作者：

Kurzatkowski, Wieslaw ^{[1
]}

Gebska-Kuczerowska, Anita ^{[2
]}

机构：

[1] Natl Inst Hyg, Natl Inst Publ Hlth, Independent Lab Streptomycetes & Fungi Imperfecti, PL-00791 Warsaw, Poland

[2] Natl Inst Hyg, Natl Inst Publ Hlth, Dept Hlth Promot & Postgrad Educ, PL-00791 Warsaw, Poland

来源：

POSTEPY MIKROBIOLOGII | 2015年 / 54卷 / 04期

关键词：

A; chrysogenum; cephalosporin C; biosynthesis; peroxisomes; FUNGAL SECONDARY METABOLISM; BETA-LACTAM ANTIBIOTICS; ENDOPLASMIC-RETICULUM; PENICILLIN BIOSYNTHESIS; ISOPENICILLIN-N; PEROXISOMES; BIOGENESIS; EXPRESSION; TRANSPORT; SYSTEM;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cephalosporin C biosynthesis is a compartmentalized process located mainly in the sub-apical, productive, non-growing cells of the hyphae, which under the conditions of the industrial technology build well-dispersed flocculent mycelia. In this paper, the cephalosporin C production by industrial strains of Acremonium chrysogenum (syn. Cephalosporium acremonium) is described, including the central role of peroxisomes in the biosynthesis and secretion of this antibiotic and other beta-lactams. The localization of the pathway of cephalosporin C biosynthesis and important transport steps of intermediates and the end-products are also discussed.

引用

页码：374 / 379

页数：6

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