Oligodendrocyte progenitors: Adult stem cells of the central nervous system?

被引：55
作者：
Crawford, A. H. [1 ,4 ]
Stockley, J. H. [1 ,3 ,4 ]
Tripathi, R. B. [2 ,5 ]
Richardson, W. D. [2 ,5 ]
Franklin, R. J. M. [1 ,3 ,4 ]
机构：
[1] Univ Cambridge, Wellcome Trust MRC Cambridge Stem Cell Inst, Cambridge CB2 1QR, England
[2] UCL, Wolfson Inst Biomed Res, London WC1E 6BT, England
[3] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Dept Clin Neurosci, Cambridge CB2 0SP, England
[4] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England
[5] UCL, Res Dept Cell & Dev Biol, London WC1E 6BT, England
来源：
EXPERIMENTAL NEUROLOGY | 2014年 / 260卷
基金：
英国惠康基金;
关键词：
Stem cell; Precursor cell; Progenitor cell; Multipotent; Oligodendrocyte; Regeneration; Remyelination; Schwann cell; Astrocyte; Neuron; MUSCLE SATELLITE CELLS; SCHWANN-CELLS; SELF-RENEWAL; SPINAL-CORD; NG2; CELLS; PRECURSOR CELLS; REMYELINATION EFFICIENCY; FOCAL DEMYELINATION; SUBVENTRICULAR ZONE; ETHIDIUM-BROMIDE;
D O I：
10.1016/j.expneurol.2014.04.027
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Oligodendrocyte progenitors (OPs) are a major proliferating cell population within the adult CNS. In response to myelin loss or increasing demand, OPs have the capacity to differentiate into mature, myelinating oligodendrocytes. The name 'oligodendrocyte progenitor' suggests restriction to the oligodendrocyte cell lineage. However, with growing evidence of the lineage plasticity of OPs both in vitro and in vivo, we discuss whether they have potential beyond that expected of dedicated progenitor cells, and hence may justify categorization as adult stem cells. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：50 / 55
页数：6
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