Oligodendrocyte progenitors: Adult stem cells of the central nervous system?

被引：55

作者：

Crawford, A. H. ^{[1
,4
]}

Stockley, J. H. ^{[1
,3
,4
]}

Tripathi, R. B. ^{[2
,5
]}

Richardson, W. D. ^{[2
,5
]}

Franklin, R. J. M. ^{[1
,3
,4
]}

机构：

[1] Univ Cambridge, Wellcome Trust MRC Cambridge Stem Cell Inst, Cambridge CB2 1QR, England

[2] UCL, Wolfson Inst Biomed Res, London WC1E 6BT, England

[3] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Dept Clin Neurosci, Cambridge CB2 0SP, England

[4] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England

[5] UCL, Res Dept Cell & Dev Biol, London WC1E 6BT, England

来源：

EXPERIMENTAL NEUROLOGY | 2014年 / 260卷

基金：

英国惠康基金;

关键词：

Stem cell; Precursor cell; Progenitor cell; Multipotent; Oligodendrocyte; Regeneration; Remyelination; Schwann cell; Astrocyte; Neuron; MUSCLE SATELLITE CELLS; SCHWANN-CELLS; SELF-RENEWAL; SPINAL-CORD; NG2; CELLS; PRECURSOR CELLS; REMYELINATION EFFICIENCY; FOCAL DEMYELINATION; SUBVENTRICULAR ZONE; ETHIDIUM-BROMIDE;

D O I：

10.1016/j.expneurol.2014.04.027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Oligodendrocyte progenitors (OPs) are a major proliferating cell population within the adult CNS. In response to myelin loss or increasing demand, OPs have the capacity to differentiate into mature, myelinating oligodendrocytes. The name 'oligodendrocyte progenitor' suggests restriction to the oligodendrocyte cell lineage. However, with growing evidence of the lineage plasticity of OPs both in vitro and in vivo, we discuss whether they have potential beyond that expected of dedicated progenitor cells, and hence may justify categorization as adult stem cells. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：50 / 55

页数：6

共 80 条

[1] Postnatal neurogenesis and gliogenesis in the olfactory bulb from NG2-expressing progenitors of the subventricular zone [J].

Aguirre, A ;

Gallo, V .

JOURNAL OF NEUROSCIENCE, 2004, 24 (46) :10530-10541

[2] Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation [J].

Asakura, A ;

Komaki, M ;

Rudnicki, MA .

DIFFERENTIATION, 2001, 68 (4-5) :245-253

[3] Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells [J].

Beauchamp, JR ;

Heslop, L ;

Yu, DSW ;

Tajbakhsh, S ;

Kelly, RG ;

Wernig, A ;

Buckingham, ME ;

Partridge, TA ;

Zammit, PS .

JOURNAL OF CELL BIOLOGY, 2000, 151 (06) :1221-1233

[4] Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons [J].

Belachew, S ;

Chittajallu, R ;

Aguirre, AA ;

Yuan, XQ ;

Kirby, M ;

Anderson, S ;

Gallo, V .

JOURNAL OF CELL BIOLOGY, 2003, 161 (01) :169-186

[5] Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus [J].

Bergles, DE ;

Roberts, JDB ;

Somogyi, P ;

Jahr, CE .

NATURE, 2000, 405 (6783) :187-191

[6] The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine [J].

Bianco, Paolo ;

Cao, Xu ;

Frenette, Paul S. ;

Mao, Jeremy J. ;

Robey, Pamela G. ;

Simmons, Paul J. ;

Wang, Cun-Yu .

NATURE MEDICINE, 2013, 19 (01) :35-42

[7] Remyelination of dorsal column axons by endogenous Schwann cells restores the normal pattern of Nav1.6 and Kv1.2 at nodes of Ranvier [J].

Black, JA ;

Waxman, SG ;

Smith, KJ .

BRAIN, 2006, 129 :1319-1329

[8] REMYELINATION BY SCHWANN-CELLS OF AXONS DEMYELINATED BY INTRASPINAL INJECTION OF 6-AMINONICOTINAMIDE IN RAT [J].

BLAKEMORE, WF .

JOURNAL OF NEUROCYTOLOGY, 1975, 4 (06) :745-757

[9] The evolving concept of a stem cell: Entity or function? [J].

Blau, HM ;

Brazelton, TR ;

Weimann, JM .

CELL, 2001, 105 (07) :829-841

[10] Properties and Fate of Oligodendrocyte Progenitor Cells in the Corpus Callosum, Motor Cortex, and Piriform Cortex of the Mouse [J].

Clarke, Laura E. ;

Young, Kaylene M. ;

Hamilton, Nicola B. ;

Li, Huiliang ;

Richardson, William D. ;

Attwell, David .

JOURNAL OF NEUROSCIENCE, 2012, 32 (24) :8173-8185

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