Antimicrobial peptides (AMPs) constitute a diverse group of bioactive molecules that provide multicellular organisms with protection against microorganisms, and microorganisms with weaponry for competition. Some AMPs can target cancer cells; thus, they are called anticancer peptides (ACPs). Due to their small size, positive charge, hydrophobicity and amphipathicity, AMPs and ACPs interact with negatively charged components of biological membranes. AMPs preferentially permeabilize microbial membranes, but ACPs additionally target mitochondrial and plasma membranes of cancer cells. The preference towards mitochondrial membranes is explained by their membrane potential, membrane composition resulting from alpha-proteobacterial origin and the fact that mitochondrial targeting signals could have evolved from AMPs. Taking into account the therapeutic potential of ACPs and millions of deaths due to cancer annually, it is of vital importance to find new cationic peptides that selectively destroy cancer cells. Therefore, to reduce the costs of experimental research, we have created a robust computational tool, CancerGram, that uses n-grams and random forests for predicting ACPs. Compared to other ACP classifiers, CancerGram is the first three-class model that effectively classifies peptides into: ACPs, AMPs and non-ACPs/non-AMPs, with AU1U amounting to 0.89 and a Kappa statistic of 0.65. CancerGram is available as a web server and R package on GitHub.
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Oregon State Univ, Coll Vet Med, Dept Clin & Biomed Sci, Corvallis, OR 97331 USAOregon State Univ, Sch Elect Engn & Comp Sci, Corvallis, OR 97331 USA
Larson, Maureen
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Kutzler, Michelle
Bionaz, Massimo
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Oregon State Univ, Dept Anim & Rangeland Sci, Corvallis, OR 97331 USAOregon State Univ, Sch Elect Engn & Comp Sci, Corvallis, OR 97331 USA
Bionaz, Massimo
Lohr, Christiane, V
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Oregon State Univ, Coll Vet Med, Dept Clin & Biomed Sci, Corvallis, OR 97331 USAOregon State Univ, Sch Elect Engn & Comp Sci, Corvallis, OR 97331 USA
Lohr, Christiane, V
Hendrix, David
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Oregon State Univ, Sch Elect Engn & Comp Sci, Corvallis, OR 97331 USA
Oregon State Univ, Dept Biochem & Biophys, Corvallis, OR 97331 USAOregon State Univ, Sch Elect Engn & Comp Sci, Corvallis, OR 97331 USA
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CSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Bhunia, Debmalya
Mondal, Prasenjit
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CSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
CSIR, Indian Inst Chem Biol, Acad Sci & Innovat Res AcSIR, 4 Raja SC Mullick Rd, Kolkata 700032, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Mondal, Prasenjit
Das, Gaurav
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CSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
CSIR, Indian Inst Chem Biol, Acad Sci & Innovat Res AcSIR, 4 Raja SC Mullick Rd, Kolkata 700032, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Das, Gaurav
Saha, Abhijit
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CSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Saha, Abhijit
Sengupta, Pallabi
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Bose Inst, Dept Biophys, P-1-12 CIT Scheme 7 M, Kolkata 700054, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Sengupta, Pallabi
Jana, Jagannath
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Bose Inst, Dept Biophys, P-1-12 CIT Scheme 7 M, Kolkata 700054, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Jana, Jagannath
Mohapatra, Saswat
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CSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
CSIR, Indian Inst Chem Biol, Acad Sci & Innovat Res AcSIR, 4 Raja SC Mullick Rd, Kolkata 700032, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Mohapatra, Saswat
Chatterjee, Subhrangsu
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Bose Inst, Dept Biophys, P-1-12 CIT Scheme 7 M, Kolkata 700054, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Chatterjee, Subhrangsu
Ghosh, Surajit
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CSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
CSIR, Indian Inst Chem Biol, Acad Sci & Innovat Res AcSIR, 4 Raja SC Mullick Rd, Kolkata 700032, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
机构:
Kyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South KoreaKyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South Korea
Boopathi, Vinothini
Subramaniyam, Sathiyamoorthy
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Insilicogen Inc, Ctr Res & Dev, Yongin 16954, Gyeonggi Do, South Korea
Dr NGP Arts & Sci Coll, Dept Biotechnol, Coimbatore 641048, Tamil Nadu, IndiaKyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South Korea
Subramaniyam, Sathiyamoorthy
Malik, Adeel
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Chungnam Natl Univ, Coll Biosci & Biotechnol, Dept Microbiol & Mol Biol, Daejeon 34134, South KoreaKyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South Korea
Malik, Adeel
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Lee, Gwang
Manavalan, Balachandran
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Ajou Univ, Sch Med, Dept Physiol, Suwon 443380, South KoreaKyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South Korea
Manavalan, Balachandran
Yang, Deok-Chun
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Kyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South KoreaKyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South Korea
机构:
Oregon State Univ, Coll Vet Med, Dept Clin & Biomed Sci, Corvallis, OR 97331 USAOregon State Univ, Sch Elect Engn & Comp Sci, Corvallis, OR 97331 USA
Larson, Maureen
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Kutzler, Michelle
Bionaz, Massimo
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Oregon State Univ, Dept Anim & Rangeland Sci, Corvallis, OR 97331 USAOregon State Univ, Sch Elect Engn & Comp Sci, Corvallis, OR 97331 USA
Bionaz, Massimo
Lohr, Christiane, V
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Oregon State Univ, Coll Vet Med, Dept Clin & Biomed Sci, Corvallis, OR 97331 USAOregon State Univ, Sch Elect Engn & Comp Sci, Corvallis, OR 97331 USA
Lohr, Christiane, V
Hendrix, David
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Oregon State Univ, Sch Elect Engn & Comp Sci, Corvallis, OR 97331 USA
Oregon State Univ, Dept Biochem & Biophys, Corvallis, OR 97331 USAOregon State Univ, Sch Elect Engn & Comp Sci, Corvallis, OR 97331 USA
机构:
CSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Bhunia, Debmalya
Mondal, Prasenjit
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机构:
CSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
CSIR, Indian Inst Chem Biol, Acad Sci & Innovat Res AcSIR, 4 Raja SC Mullick Rd, Kolkata 700032, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Mondal, Prasenjit
Das, Gaurav
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CSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
CSIR, Indian Inst Chem Biol, Acad Sci & Innovat Res AcSIR, 4 Raja SC Mullick Rd, Kolkata 700032, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Das, Gaurav
Saha, Abhijit
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CSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Saha, Abhijit
Sengupta, Pallabi
论文数: 0引用数: 0
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机构:
Bose Inst, Dept Biophys, P-1-12 CIT Scheme 7 M, Kolkata 700054, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Sengupta, Pallabi
Jana, Jagannath
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Bose Inst, Dept Biophys, P-1-12 CIT Scheme 7 M, Kolkata 700054, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Jana, Jagannath
Mohapatra, Saswat
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CSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
CSIR, Indian Inst Chem Biol, Acad Sci & Innovat Res AcSIR, 4 Raja SC Mullick Rd, Kolkata 700032, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Mohapatra, Saswat
Chatterjee, Subhrangsu
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Bose Inst, Dept Biophys, P-1-12 CIT Scheme 7 M, Kolkata 700054, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
Chatterjee, Subhrangsu
Ghosh, Surajit
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h-index: 0
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CSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
CSIR, Indian Inst Chem Biol, Acad Sci & Innovat Res AcSIR, 4 Raja SC Mullick Rd, Kolkata 700032, IndiaCSIR, Indian Inst Chem Biol, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
机构:
Kyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South KoreaKyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South Korea
Boopathi, Vinothini
Subramaniyam, Sathiyamoorthy
论文数: 0引用数: 0
h-index: 0
机构:
Insilicogen Inc, Ctr Res & Dev, Yongin 16954, Gyeonggi Do, South Korea
Dr NGP Arts & Sci Coll, Dept Biotechnol, Coimbatore 641048, Tamil Nadu, IndiaKyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South Korea
Subramaniyam, Sathiyamoorthy
Malik, Adeel
论文数: 0引用数: 0
h-index: 0
机构:
Chungnam Natl Univ, Coll Biosci & Biotechnol, Dept Microbiol & Mol Biol, Daejeon 34134, South KoreaKyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South Korea
Malik, Adeel
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机构:
Lee, Gwang
Manavalan, Balachandran
论文数: 0引用数: 0
h-index: 0
机构:
Ajou Univ, Sch Med, Dept Physiol, Suwon 443380, South KoreaKyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South Korea
Manavalan, Balachandran
Yang, Deok-Chun
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South KoreaKyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin 17104, Gyeonggi Do, South Korea