Axonal regeneration inhibitors: emerging therapeutic options

被引：7
作者：
Rosochowicz, T. W. [1 ]
Wrotek, S. [1 ]
Kozak, W. [1 ]
机构：
[1] Nicholas Copernicus Univ, Torun, Poland
来源：
ACTA NEUROLOGICA BELGICA | 2015年 / 115卷 / 04期
关键词：
Nogo-A; MAG; OMgp; Regeneration of the central nervous system; MYELIN-ASSOCIATED GLYCOPROTEIN; SPINAL-CORD; NEURITE OUTGROWTH; SIGNALING PATHWAY; RECEPTOR; RHO; CNS; IDENTIFICATION; PROTEIN; GROWTH;
D O I：
10.1007/s13760-015-0425-0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
For the most part, the central nervous system is unable to regenerate. The majority of injuries of vascular, inflammatory, degenerative and traumatic aetiology lead to an irreversible loss of central nervous system function. The paper presents the role of Nogo-A, MAG and OMgp proteins in the inhibition of central nervous system regeneration, and their potential clinical significance.
引用
收藏
页码：527 / 532
页数：6
相关论文
共 50 条
[31]   TAT-NEP1-40 as a novel therapeutic candidate for axonal regeneration and functional recovery after stroke [J].
Gou, Xingchun ;
Wang, Qiang ;
Yang, Qianzi ;
Xu, Lixian ;
Xiong, Lize .
JOURNAL OF DRUG TARGETING, 2011, 19 (02) :86-95
[32]   Rabs and axonal regeneration [J].
Yong, Cheryl Qian Ying ;
Tang, Bor Luen .
NEURAL REGENERATION RESEARCH, 2019, 14 (04) :566-569
[33]   Age-related loss of axonal regeneration is reflected by the level of local translation [J].
van Erp, Susan ;
van Berkel, Annemiek A. ;
Feenstra, Eline M. ;
Sahoo, Pabitra K. ;
Wagstaff, Laura J. ;
Twiss, Jeffery L. ;
Fawcett, James W. ;
Eva, Richard ;
ffrench-Constant, Charles .
EXPERIMENTAL NEUROLOGY, 2021, 339
[34]   Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS [J].
Hirokawa, Tomoko ;
Zou, Yixiao ;
Kurihara, Yuji ;
Jiang, Zhaoxin ;
Sakakibara, Yusuke ;
Ito, Hiromu ;
Funakoshi, Kengo ;
Kawahara, Nobutaka ;
Goshima, Yoshio ;
Strittmatter, Stephen M. ;
Takei, Kohtaro .
SCIENTIFIC REPORTS, 2017, 7
[35]   Schwann Cells Provide Iron to Axonal Mitochondria and Its Role in Nerve Regeneration [J].
Mietto, Bruno Siqueira ;
Jhelum, Priya ;
Schulz, Katrin ;
David, Samuel .
JOURNAL OF NEUROSCIENCE, 2021, 41 (34) :7300-7313
[36]   The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury [J].
Sekine, Yuichi ;
Siegel, Chad S. ;
Sekine-Konno, Tomoko ;
Cafferty, William B. J. ;
Strittmatter, Stephen M. .
SCIENCE SIGNALING, 2018, 11 (524)
[37]   Myelin-based inhibitors of oligodendrocyte myelination: clues from axonal growth and regeneration [J].
Feng Mei ;
S.Y.Christin Chong ;
Jonah R.Chan .
NeuroscienceBulletin, 2013, 29 (02) :177-188
[38]   Myelin-based inhibitors of oligodendrocyte myelination: clues from axonal growth and regeneration [J].
Feng Mei ;
S. Y. Christin Chong ;
Jonah R. Chan .
Neuroscience Bulletin, 2013, 29 :177-188
[39]   Expression profile of receptors for myelin-associated inhibitors of axonal regeneration in the intact and injured mouse central nervous system [J].
Barrette, Benoit ;
Vallieres, Nicolas ;
Dube, Marthe ;
Lacroix, Steve .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2007, 34 (04) :519-538
[40]   Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration [J].
Kubo, Takekazu ;
Hata, Katsuhiko ;
Yamaguchi, Atsushi ;
Yamashita, Toshihide .
CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (24) :2493-2499
12345