Axonal regeneration inhibitors: emerging therapeutic options

被引：8
作者：
Rosochowicz, T. W. [1 ]
Wrotek, S. [1 ]
Kozak, W. [1 ]
机构：
[1] Nicholas Copernicus Univ, Torun, Poland
来源：
ACTA NEUROLOGICA BELGICA | 2015年 / 115卷 / 04期
关键词：
Nogo-A; MAG; OMgp; Regeneration of the central nervous system; MYELIN-ASSOCIATED GLYCOPROTEIN; SPINAL-CORD; NEURITE OUTGROWTH; SIGNALING PATHWAY; RECEPTOR; RHO; CNS; IDENTIFICATION; PROTEIN; GROWTH;
D O I：
10.1007/s13760-015-0425-0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
For the most part, the central nervous system is unable to regenerate. The majority of injuries of vascular, inflammatory, degenerative and traumatic aetiology lead to an irreversible loss of central nervous system function. The paper presents the role of Nogo-A, MAG and OMgp proteins in the inhibition of central nervous system regeneration, and their potential clinical significance.
引用
收藏
页码：527 / 532
页数：6
相关论文
共 50 条
  • [21] In-silico and Molecular Analysis of Reticulon 4asNovel therapeutic option for axonal regeneration
    Kanwal, Sumaira
    Perveen, Shazia
    JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, 2019, 69 (10) : 1425 - 1430
  • [22] Transfection with AAV-NgR1siRNA on axonal regeneration of optic nerve after injury
    Su, Ying
    Li, Yubo
    Yang, Rufei
    Hu, Qi
    Wang, Feng
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017, 10 (02): : 2327 - 2332
  • [23] Axonal regeneration of optic nerve after crush in Nogo66 receptor knockout mice
    Su, Ying
    Wang, Feng
    Teng, Yan
    Zhao, Shi-guang
    Cui, Hao
    Pan, Shang-ha
    NEUROSCIENCE LETTERS, 2009, 460 (03) : 223 - 226
  • [24] ROCK Inhibitors as Emerging Therapeutic Candidates for Sarcomas
    Micuda, S.
    Rosel, D.
    Ryska, A.
    Brabek, J.
    CURRENT CANCER DRUG TARGETS, 2010, 10 (02) : 127 - 134
  • [25] Axonal regeneration and sprouting as a potential therapeutic target for nervous system disorders
    Marshall, Katherine L.
    Farah, Mohamed H.
    NEURAL REGENERATION RESEARCH, 2021, 16 (10) : 1901 - 1910
  • [26] Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration
    Costa, Goncalo
    Ribeiro, Filipa F. F.
    Sebastiao, Ana M. M.
    Muir, Elizabeth M. M.
    Vaz, Sandra H. H.
    FRONTIERS IN NEUROSCIENCE, 2022, 16
  • [27] Pioneering Studies on the Mechanisms of Axonal Regeneration
    Snow, Diane M.
    DEVELOPMENTAL NEUROBIOLOGY, 2011, 71 (09) : 785 - 789
  • [28] Towards axonal regeneration and neuroprotection in glaucoma: Rho kinase inhibitors as promising therapeutics
    Van de Velde, Sarah
    De Groef, Lies
    Stalmans, Ingeborg
    Moons, Lieve
    Van Hove, Inge
    PROGRESS IN NEUROBIOLOGY, 2015, 131 : 105 - 119
  • [29] Roles of channels and receptors in the growth cone during PNS axonal regeneration
    Shim, Sangwoo
    Ming, Guo-li
    EXPERIMENTAL NEUROLOGY, 2010, 223 (01) : 38 - 44
  • [30] Axonal regeneration of optic nerve after crush after PirBsiRNA transfection
    Su, Ying
    Yu, Zhimei
    Guo, Xin
    Wang, Feng
    Chen, Fei
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017, 10 (09): : 9633 - 9638
12345