Role of the RIG-I-like receptors in antiviral response

被引：0

作者：

Jablonska, Agnieszka ^{[1
]}

Paradowska, Edyta ^{[1
]}

机构：

[1] Inst Biol Med PAN, Pracownia Wirusol Mol & Chem Biol, PL-93232 Lodz, Poland

来源：

POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ | 2014年 / 68卷

关键词：

innate immunity; cell receptors; virus; interferon; DOUBLE-STRANDED-RNA; INDUCIBLE GENE-I; HERPES-SIMPLEX-VIRUS; HEPATITIS-C VIRUS; INTERFERON REGULATORY FACTOR-3; INNATE IMMUNE-RESPONSE; NF-KAPPA-B; NEGATIVE REGULATION; ADAPTER PROTEIN; E3; LIGASE;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The innate nonspecific immunity is the first line of defense against viral infection. Toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are two main receptor families detecting viral nucleic acid. So far, three RLR family members were characterized: RIG-I, MDA5 and LGP2. RLR constitute a family of cytoplasmic helicases, which recognized intracellular single-stranded and double-stranded RNA that is introduced to cytosol during viral infection and replication. In this work we review the current knowledge about the mechanisms of viral recognition by RIG-I-like receptors and their signaling pathways for the activation of type I interferons and pro-inflammatory cytokines synthesis.

引用

页码：541 / 556

页数：16

共 107 条

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