Application of nucleic acid-lipid conjugates for the programmable organisation of liposomal modules

被引:56
作者
Beales, Paul A. [1 ]
Vanderlick, T. Kyle [2 ]
机构
[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England
[2] Yale Univ, Dept Chem & Environm Engn, New Haven, CT 06510 USA
关键词
Lipid vesicles; DNA amphiphiles; Directed assembly; Compartmentalization; Bionanotechnology; SOLID-LIKE DOMAINS; VESICLE FUSION; SYNTHETIC BIOLOGY; ARTIFICIAL CELL; PHOSPHOLIPID-MEMBRANES; PHASE-TRANSITIONS; TETHERED VESICLE; PNA AMPHIPHILES; DRUG-DELIVERY; DNA COMPLEXES;
D O I
10.1016/j.cis.2013.12.009
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
We present a critical review of recent work related to the assembly of multicompartment liposome clusters using nucleic acids as a specific recognition unit to link liposomal modules. The asymmetry in nucleic acid binding to its non-self complementary strand allows the controlled association of different compartmental modules into composite systems. These biomimetic multicompartment architectures could have future applications in chemical process control, drug delivery and synthetic biology. We assess the different methods of anchoring DNA to lipid membrane surfaces and discuss how lipid and DNA properties can be tuned to control the morphology and properties of liposome superstructures. We consider different methods for chemical communication between the contents of liposomal compartments within these clusters and assess the progress towards making this chemical mixing efficient, switchable and chemically specific. Finally, given the current state of the art, we assess the outlook for future developments towards functional modular networks of liposomes. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:290 / 305
页数:16
相关论文
共 145 条
[1]   Probing the structure of supported membranes and tethered oligonucleotides by fluorescence interference contrast microscopy [J].
Ajo-Franklin, CM ;
Yoshina-Ishii, C ;
Boxer, SG .
LANGMUIR, 2005, 21 (11) :4976-4983
[2]   Adhesion-induced domain formation by interplay of long-range repulsion and short-range attraction force: A model membrane study [J].
Albersdorfer, A ;
Feder, T ;
Sackmann, E .
BIOPHYSICAL JOURNAL, 1997, 73 (01) :245-257
[3]   Assembling materials with DNA as the guide [J].
Aldaye, Faisal A. ;
Palmer, Alison L. ;
Sleiman, Hanadi F. .
SCIENCE, 2008, 321 (5897) :1795-1799
[4]   Phospholipid membranes decorated by cholesterol-based oligonucleotides as soft hybrid nanostructures [J].
Banchelli, Martina ;
Betti, Francesca ;
Berti, Debora ;
Caminati, Gabriella ;
Bombelli, Francesca Baldelli ;
Brown, Tom ;
Wilhelmsson, L. Marcus ;
Norden, Bengt ;
Baglioni, P. .
JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 112 (35) :10942-10952
[5]   Modulation of Density and Orientation of Amphiphilic DNA on Phospholipid Membranes. II. Vesicles [J].
Banchelli, Martina ;
Gambinossi, Filippo ;
Durand, Adeline ;
Caminati, Gabriella ;
Brown, Tom ;
Berti, Debora ;
Baglioni, Piero .
JOURNAL OF PHYSICAL CHEMISTRY B, 2010, 114 (21) :7348-7358
[6]   DNA nanomachines [J].
Bath, Jonathan ;
Turberfield, Andrew J. .
NATURE NANOTECHNOLOGY, 2007, 2 (05) :275-284
[7]   Fluorescence probe partitioning between Lo/Ld phases in lipid membranes [J].
Baumgart, Tobias ;
Hunt, Geoff ;
Farkas, Elaine R. ;
Webb, Watt W. ;
Feigenson, Gerald W. .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2007, 1768 (09) :2182-2194
[8]   Solid-like domains in fluid membranes [J].
Beales, PA ;
Gordon, VD ;
Zhao, ZJ ;
Egelhaaf, SU ;
Poon, WCK .
JOURNAL OF PHYSICS-CONDENSED MATTER, 2005, 17 (45) :S3341-S3346
[9]   Specific binding of different vesicle populations by the hybridization of membrane-anchored DNA [J].
Beales, Paul A. ;
Vanderlick, T. Kyle .
JOURNAL OF PHYSICAL CHEMISTRY A, 2007, 111 (49) :12372-12380
[10]   Specific adhesion between DNA-functionalized "Janus'' vesicles: size-limited clusters [J].
Beales, Paul A. ;
Nam, Jin ;
Vanderlick, T. Kyle .
SOFT MATTER, 2011, 7 (05) :1747-1755