NFAT: ubiquitous regulator of cell differentiation and adaptation

被引：267

作者：

Horsley, V ^{[1
]}

Pavlath, GK ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 USA

来源：

JOURNAL OF CELL BIOLOGY | 2002年 / 156卷 / 05期

关键词：

NFAT; development; adaptation; calcium signaling; cell fate;

D O I：

10.1083/jcb.200111073

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors whose activation is controlled by calcineurin, a Ca2+-dependent phosphatase. Originally identified in T cells as inducers of cytokine gene expression, NFAT proteins play varied roles in cells outside of the immune system. This review addresses the recent data implicating NFAT in the control of gene expression influencing the development and adaptation of numerous mammalian cell types.

引用

页码：771 / 774

页数：4

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